4 documents found, page 1 of 1
Model-guided development of an evolutionarily stable yeast chassis
Pereira, Filipa; Lopes, Hélder; Maia, Paulo; Meyer, Britta; Nocon, Justyna; Jouhten, Paula; Konstantinidis, Dimitrios; Kafkia, Eleni; Rocha, MiguelAbstract First-principle metabolic modelling holds potential for designing microbial chassis that are resilient against phenotype reversal due to adaptive mutations. Yet, the theory of model-based chassis design has rarely been put to rigorous experimental test. Here, we report the development of Saccharomyces cerevisiae chassis strains for dicarboxylic acid production using genome-scale metabolic modelling. Th...
Detection and correlation of single and concomitant TP53, PTEN, and CDKN2A alte...
Pess?a, Igor Andrade; Amorim, Carolina Koury; Ferreira, Wallax Augusto Silva; Sagica, Fernanda; Brito, Jos? Reginaldo; Othman, Moneeb; Meyer, BrittaThis research was funded partially by Funda??o de Amparo ? Pesquisa do Estado do Par? (FAPESPA, Bel?m, PA) (ICAAF 075/2014).; Universidade Federal do Par?. Programa de P?s-gradua??o em Gen?tica e Biologia Molecular. Bel?m, PA, Brazil / Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Laborat?rio de Cultura de Tecidos e Citogen?tica. Ananindeua, PA, Brasil / Jena University Hospi...
Yeast chassis design for dicarboxylic acids production
Pereira, Filipa; Lopes, Helder; Maia, Paulo; Meyer, Britta; Konstantinidis, Dimitrios; Kafkia, Eleni; Kötter, Peter; Rocha, I.; Patil, Kiran R.
High rates of submicroscopic aberrations in karyotypically normal acute lymphob...
Othman, Moneeb A. K.; Melo, Joana B.; Carreira, Isabel M.; Rincic, Martina; Glaser, Anita; Grygalewicz, Beata; Gruhn, Bernd; Wilhelm, KathleenBackground: Acute lymphoblastic leukemia (ALL) is not a single uniform disease. It consists of several subgroups with different cytogenetic and molecular genetic aberrations, clinical presentations and outcomes. Banding cytogenetics plays a pivotal role in the detection of recurrent chromosomal rearrangements and is the starting point of genetic analysis in ALL, still. Nowadays, molecular (cyto)genetic tools pr...