Made available in DSpace on 2022-04-29T08:46:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-28; Center for Information Technology; Center for Scientific Review; National Institutes of Health; Office of Extramural Research, National Institutes of Health; Office of Research Infrastructure Programs, National Institutes of Health; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fu...
Made available in DSpace on 2022-04-29T08:46:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-12-01; National Institute of General Medical Sciences; As whole-genome sequencing (WGS) becomes the gold standard tool for studying population genomics and medical applications, data on diverse non-European and admixed individuals are still scarce. Here, we present a high-coverage WGS dataset of 1,171 highly a...
Made available in DSpace on 2022-04-29T08:32:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; National Institutes of Health; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation in...
Made available in DSpace on 2020-12-12T01:31:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-01; Genome-wide associations studies have repeatedly identified the major histocompatibility complex genomic region (6p21.3) as key in immune pathologies. Researchers have also aimed to extend the biological interpretation of associations by focusing directly on human leukocyte antigen (HLA) polymorphisms a...
Made available in DSpace on 2020-12-12T02:19:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Human leukocyte antigen-C (HLA-C) is a classical HLA class I molecule that binds and presents peptides to cytotoxic T lymphocytes in the cell surface. HLA-C has a dual function because it also interacts with Killer-cell immunoglobulin-like receptors (KIR) receptors expressed in natural killer and T cell...