2 documents found, page 1 of 1
Promoter methylation of the MGAT3 and BACH2 genes correlates with the compositi...
Klasic, M; Markulin, D; Vojta, A; Samaržija, I; Biruš, I; Dobrinic, P; Ventham, N; Trbojevic-Akmacic, I; Šimurina, M; Štambuk, J; Razdorov, GBackground: Many genome- and epigenome-wide association studies (GWAS and EWAS) and studies of promoter methylation of candidate genes for inflammatory bowel disease (IBD) have demonstrated significant associations between genetic and epigenetic changes and IBD. Independent GWA studies have identified genetic variants in the BACH2, IL6ST, LAMB1, IKZF1, and MGAT3 loci to be associated with both IBD and immunoglo...
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel D...
Pereira, CC; Durães, C; Coelho, R; Grácio, D; Silva, M; Peixoto, A; Lago, P; Pereira, M; Catarino, T; Pinho, S; Teixeira, JP; Macedo, G; Annese, VInflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Croh...