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Six transiting planets and a chain of Laplace resonances in TOI-178

Leleu, A.; Alibert, Y.; Hara, N. C.; Hooton, M. J.; Wilson, T. G.; Robutel, P.; Delisle, J. -B.; Laskar, J.; Hoyer, S.; Lovis, C.; Bryant, E. M.

Determining the architecture of multi-planetary systems is one of the cornerstones of understanding planet formation and evolution. Resonant systems are especially important as the fragility of their orbital configuration ensures that no significant scattering or collisional event has taken place since the earliest formation phase when the parent protoplanetary disc was still present. In this context, TOI-178 h...


Association of positive and negative life events with cognitive performance and...

Castanho, T. C.; Santos, N. C.; Meleiro-Neves, C.; Neto, S.; Moura, G. R.; Santos, M.; Cruz, A.R.; Cunha, O.; Castro Rodrigues, A.; Rodrigues, A. J.

Objectives: Life events have important effects on psychological well-being. Yet, studies have mainly focused on exploring the impact of traumatic and negative experiences on health and well-being, with positive events receiving marginal attention. In this study, we investigated the association between negative and positive life events, cognitive performance and psychological status in older individuals. Method:...


The TROY project: Searching for co-orbital bodies to known planets: I. Project ...

Lillo-Box, J.; Barrado, D.; Figueira, P.; Leleu, A.; Santos, N. C.; Correia, A. C. M.; Robutel, P.; Faria, J. P.

The detection of Earth-like planets, exocomets or Kuiper belts show that the different components found in the solar system should also be present in other planetary systems. Trojans are one of these components and can be considered fossils of the first stages in the life of planetary systems. Their detection in extrasolar systems would open a new scientific window to investigate formation and migration process...


The TROY project: II. Multi-technique constraints on exotrojans in nine planeta...

Lillo-Box, J.; Leleu, A.; Parviainen, H.; Figueira, P.; Mallonn, M.; Correia, A. C. M.; Santos, N. C.; Robutel, P.; Lendl, M.; Boffin, H. M. J.

Co-orbital bodies are the byproduct of planet formation and evolution, as we know from the solar system. Although planet-size co-orbitals do not exists in our planetary system, dynamical studies show that they can remain stable for long periods of time in the gravitational well of massive planets. Should they exist, their detection is feasible with the current instrumentation. Aims. In this paper, we present ne...


In vivo efficacy of measles virus fusion protein-derived peptides is modulated ...

Figueira, T. N.; Palermo, L. M.; Veiga, A. S.; Huey, D.; Alabi, C. A.; Santos, N. C.; Welsch, J. C.; Mathieu, C.; Horvat, B.; Niewiesk, S.; Moscona, A.

© 2016 American Society for Microbiology. All Rights Reserved.; Measles virus (MV) infection is undergoing resurgence and remains one of the leading causes of death among young children worldwide despite the availability of an effective measles vaccine. MV infects its target cells by coordinated action of the MV hemagglutinin (H) and fusion (F) envelope glycoproteins; upon receptor engagement by H, the prefusio...


Lipid selectivity in novel antimicrobial peptides : implication on antimicrobia...

Maturana, P.; Martinez, M.; Noguera, M. E.; Santos, N. C.; Disalvo, E. A.; Semorile, L.; Maffia, P. C.; Hollmann, A.

© 2017 Elsevier B.V. All rights reserved; Antimicrobial peptides (AMPs) are small cationic molecules that display antimicrobial activity against awide range of bacteria, fungi and viruses. For an AMP to be considered as a therapeutic option, it musthave not only potent antibacterial properties but also low hemolytic and cytotoxic activities [1]. Eventhough many studies have been conducted in order to correlate ...


Higher membrane fluidity mediates the increased subcutaneous fatty acid content...

Lopes, P. A.; Martins, A. P.; Martins, S. V.; Madeira, M. S.; Santos, N. C.; Moura, T. F.; Prates, J. A. M.; Soveral, G.

© The Animal Consortium 2016; The production of pork with moderate amounts of intramuscular fat (IMF) without an increase in subcutaneous fat is highly desirable for the meat industry. Several studies indicate that dietary protein reduction during the growing-finishing period of pigs enhances IMF content, but its consequence on carcass fat deposition is still contradictory. In this study, we hypothesized that t...


Decellularized human colorectal cancer matrices polarize macrophages towards an...

Pinto, M. L.; Rios, E.; Silva, A. C.; Neves, S. C.; Caires, H. R.; Pinto, A. T.; Durães, C.; Carvalho, F. A.; Cardoso, A. P.; Santos, N. C.

© 2017 Elsevier Ltd; Macrophages are frequently identified in solid tumors, playing important roles in cancer progression. Their remarkable plasticity makes them very sensitive to environmental factors, including the extracellular matrix (ECM). In the present work, we investigated the impact of human colorectal tumor matrices on macrophage polarization and on macrophage-mediated cancer cell invasion. Accordingl...


The SOPHIE search for northern extrasolar planets: X. Detection and characteriz...

Hébrard, G.; Arnold, L.; Forveille, T.; Correia, A. C. M.; Laskar, J.; Bonfils, X.; Boisse, I.; Díaz, R. F.; Hagelberg, J.; Sahlmann, J.; Santos, N. C.

We present new radial velocity measurements of eight stars that were secured with the spectrograph SOPHIE at the 193 cm telescope of the Haute-Provence Observatory. The measurements allow detecting and characterizing new giant extrasolar planets. The host stars are dwarfs of spectral types between F5 and K0 and magnitudes of between 6.7 and 9.6; the planets have minimum masses Mp sin i of between 0.4 to 3.8 MJu...


An extreme planetary system around HD 219828: one long-period super Jupiter to ...

Santos, N. C.; Santerne, A.; Faria, J. P.; Rey, J.; Correia, A. C. M.; Laskar, J.; Udry, S.; Adibekyan, V.; Bouchy, F.; Delgado-Mena, E.; Melo, C.

Context. With about 2000 extrasolar planets confirmed, the results show that planetary systems have a whole range of unexpected properties. This wide diversity provides fundamental clues to the processes of planet formation and evolution. Aims: We present a full investigation of the HD 219828 system, a bright metal-rich star for which a hot Neptune has previously been detected. Methods: We used a set of HARPS, ...


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