13 documents found, page 1 of 2
Post-tuberculosis lung disease: a comparison of Brazilian, Italian, and Mexican...
Silva,Denise Rossato; Freitas,Alana Ambos; Guimarães,Amanda Reis; D’Ambrosio,Lia; Centis,Rosella; Muñoz-Torrico,Marcela; Visca,DinaABSTRACT Objective: To evaluate lung function in a cohort of patients with a history of pulmonary tuberculosis in Brazil, as well as to evaluate the decline in lung function over time and compare it with that observed in similar cohorts in Mexico and Italy. Methods: The three cohorts were compared in terms of age, smoking status, pulmonary function test results, six-minute walk test results, and arterial blood ...
Bedaquiline-containing regimens and multidrug-resistant tuberculosis: a systema...
Hatami,Hossein; Sotgiu,Giovanni; Bostanghadiri,Narjess; Abadi,Sahel Shafiee Dolat; Mesgarpour,Bita; Goudarzi,Hossein; Migliori,Giovanni BattistaABSTRACT Objective: Multidrug-resistant tuberculosis (MDR-TB) is a life-threatening infectious disease. Treatment requires multiple antimicrobial agents used for extended periods of time. The present study sought to evaluate the treatment success rate of bedaquiline-based regimens in MDR-TB patients. Methods: This was a systematic review and meta-analysis of studies published up to March 15, 2021. The pooled tr...
Tuberculosis and COVID-19, the new cursed duet: what differs between Brazil and...
Silva,Denise Rossato; Mello,Fernanda Carvalho de Queiroz; D’Ambrosio,Lia; Centis,Rosella; Dalcolmo,Margareth Pretti; Migliori,Giovanni BattistaABSTRACT On April 1st, 2020, COVID-19 surpassed tuberculosis regarding the number of deaths per day worldwide. The combination of tuberculosis and COVID-19 has great potential for morbidity and mortality. In addition, the COVID-19 pandemic has had a significant impact on the diagnosis and treatment of tuberculosis. In this review article, we address concurrent tuberculosis and COVID-19, with particular regard t...
Time course of exercise capacity in patients recovering from COVID-19-associate...
Zampogna,Elisabetta; Ambrosino,Nicolino; Saderi,Laura; Sotgiu,Giovanni; Bottini,Paola; Pignatti,Patrizia; Centis,Rosella; Migliori,Giovanni BattistaABSTRACT Objective: High prevalences of muscle weakness and impaired physical performance in hospitalized patients recovering from COVID-19-associated pneumonia have been reported. Our objective was to determine whether the level of exercise capacity after discharge would affect long-term functional outcomes in these patients. Methods: From three to five weeks after discharge from acute care hospitals (T0), pat...
Shortened tuberculosis treatment regimens: what is new?
Silva,Denise Rossato; Mello,Fernanda Carvalho de Queiroz; Migliori,Giovanni BattistaABSTRACT Given the global burden of tuberculosis, shortened treatment regimens with existing or repurposed drugs are needed to contribute to tuberculosis control. The long duration of treatment of drug-susceptible tuberculosis (DS-TB) is associated with nonadherence and loss to follow up, and the treatment success rate of multidrug-resistant tuberculosis (MDR-TB) is low (approximately 50%) with longer regimens....
Managing severe tuberculosis and its sequelae: from intensive care to surgery a...
Tiberi,Simon; Torrico,Marcela Muñoz; Rahman,Ananna; Krutikov,Maria; Visca,Dina; Silva,Denise Rossato; Kunst,Heinke; Migliori,Giovanni BattistaABSTRACT Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) continue to challenge physicians and public health specialists. Global treatment outcomes continue to be unsatisfactory, positive outcomes being achieved in only 54% of patients. Overall outcomes are even worse in patients infected with highly resistant strains. Treating MDR-/XDR-TB is difficult because of fr...
International collaboration among medical societies is an effective way to boos...
Migliori,Giovanni Battista; Centis,Rosella; D’Ambrosio,Lia; Silva,Denise Rossato; Rendon,AdrianABSTRACT Objective: Most studies of tuberculosis originate from high-income countries with a low incidence of tuberculosis. A review of the scientific production on tuberculosis in Latin American countries, most of which are low- or middle-income countries (some with high or intermediate tuberculosis incidence rates), would improve the understanding of public health challenges, clinical needs, and research prio...
Predictors of mortality among intensive care unit patients coinfected with tube...
Ferreira,Marcia Danielle; Neves,Cynthia Pessoa das; Souza,Alexandra Brito de; Beraldi-Magalhães,Francisco; Migliori,Giovanni BattistaABSTRACT Objective: To identify factors predictive of mortality in patients admitted to the ICU with tuberculosis (TB)/HIV coinfection in the Manaus, Amazon Region. Methods: This was a retrospective cohort study of TB/HIV coinfected patients over 18 years of age who were admitted to an ICU in the city of Manaus, Brazil, between January of 2011 and December of 2014. Sociodemographic, clinical, and laboratory var...
Epidemiological aspects, clinical manifestations, and prevention of pediatric t...
Carvalho,Anna Cristina Calçada; Cardoso,Claudete Aparecida Araújo; Martire,Terezinha Miceli; Migliori,Giovanni Battista; Sant’Anna,Clemax CoutoABSTRACT Tuberculosis continues to be a public health priority in many countries. In 2015, tuberculosis killed 1.4 million people, including 210,000 children. Despite the recent progress made in the control of tuberculosis in Brazil, it is still one of the countries with the highest tuberculosis burdens. In 2015, there were 69,000 reported cases of tuberculosis in Brazil and tuberculosis was the cause of 4,500 ...
New and repurposed drugs to treat multidrug- and extensively drug-resistant tub...
Silva,Denise Rossato; Dalcolmo,Margareth; Tiberi,Simon; Arbex,Marcos Abdo; Munoz-Torrico,Marcela; Duarte,Raquel; D’Ambrosio,Lia; Visca,DinaABSTRACT Multidrug-resistant and extensively drug-resistant tuberculosis (MDR-TB and XDR-TB, respectively) continue to represent a challenge for clinicians and public health authorities. Unfortunately, although there have been encouraging reports of higher success rates, the overall rate of favorable outcomes of M/XDR-TB treatment is only 54%, or much lower when the spectrum of drug resistance is beyond that of...