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Endobronchial Amphotericin B to Treat Hemoptysis in an Inoperable Patient with ...

Pinto, M; Rodrigues, J; Silva, M; Maia, D; Miguel, A

A 37-year-old man presented with chronic cavitary pulmonary aspergillosis and hemoptysis refractory to systemic antifungal therapy with voriconazole and bronchial artery embolization. Surgical excision was unfeasible due to the patient's refusal of blood transfusions. Ten sessions of intracavitary instillation of amphotericin B via flexible bronchoscopy were then performed. Hemoptysis cessation and aspergilloma...


Repercussions of the COVID-19 Pandemic in the Emergency Department of Gynecolog...

Jovina Domingues, S; Ormonde, M; Miguel, A; Martins, A; Saavedra, I; Silva, MC

Objective. COVID-19 has spread worldwide and Portugal decreed the State of Emergency on March 18th, 2020. During this period, the population was encouraged to stay at home. Still, there were no restrictions on access to health care. Therefore, we aimed to compare the major causes for attending the Obstetrics and Gynaecology Emergency Department (ED) from a referral centre (Maternidade Dr. Alfredo da Costa, in L...


Ophthalmic adverse drug reactions to systemic drugs: a systematic review

Miguel, A; Henriques, F; Azevedo, LF; Pereira, AC

PURPOSE: To perform a comprehensive and systematic review regarding ophthalmic adverse drug reactions (ADRs) to systemic drugs to: (i) systematically summarize existing evidence, (ii) identify areas, ophthalmic ADRs or drugs that lacked systematization or assessment (namely drugs with original studies characterizing specific ophthalmic ADRs but without causality assessment nor without meta-analysis). METHODS: S...


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