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Genetic signatures of selection in southern Angolan sheep unravel adaptation fo...

Teixeira, F; Chiaia, H; Sebastino, K; Gaspar, J; Afonso, P; Ngola, S; Simão, C; Casimiro, J; Pires, J; Miguel, A; Dala, E; Pires, M; Nanga, P; Santos, D

Natural and artificial selection in African sheep populations has left distinctive genomic signatures. In southern Angola, pastoralist tribes breed fat-tailed sheep adapted to arid and mesic savannas for protein and cultural purposes. This study aims to identify candidate genes associated with productivity and adaptation in these sheep. We sequenced genomes from Namibe (n = 3) and Cunene (n = 5) and compared th...


Uncovering the genetic diversity of native bovine from South Angola

Sebastino, K; Chiaia, H; Afonso, P; Gaspar, J; Teixeira, F; Ngola, S; Simão, C; Casimiro, J; Nanga, P; Miguel, A; Gomes, L; Alexandre, A; Leitão, A

cattle in Angola and how they relate to other breeds. In Africa we find Bos taurus and Bos indicus cattle and a hybrid also known as Sanga cattle. The most dominant cattle in Angola are Sanga which name varies according to the location and native language of the region, existing 11 different denominations, which conservation status in unknown. Sampling was performed between 2023 and 2024 in different provinces....


Endobronchial Amphotericin B to Treat Hemoptysis in an Inoperable Patient with ...

Pinto, M; Rodrigues, J; Silva, M; Maia, D; Miguel, A

A 37-year-old man presented with chronic cavitary pulmonary aspergillosis and hemoptysis refractory to systemic antifungal therapy with voriconazole and bronchial artery embolization. Surgical excision was unfeasible due to the patient's refusal of blood transfusions. Ten sessions of intracavitary instillation of amphotericin B via flexible bronchoscopy were then performed. Hemoptysis cessation and aspergilloma...


Repercussions of the COVID-19 Pandemic in the Emergency Department of Gynecolog...

Jovina Domingues, S; Ormonde, M; Miguel, A; Martins, A; Saavedra, I; Silva, MC

Objective. COVID-19 has spread worldwide and Portugal decreed the State of Emergency on March 18th, 2020. During this period, the population was encouraged to stay at home. Still, there were no restrictions on access to health care. Therefore, we aimed to compare the major causes for attending the Obstetrics and Gynaecology Emergency Department (ED) from a referral centre (Maternidade Dr. Alfredo da Costa, in L...


Ophthalmic adverse drug reactions to systemic drugs: a systematic review

Miguel, A; Henriques, F; Azevedo, LF; Pereira, AC

PURPOSE: To perform a comprehensive and systematic review regarding ophthalmic adverse drug reactions (ADRs) to systemic drugs to: (i) systematically summarize existing evidence, (ii) identify areas, ophthalmic ADRs or drugs that lacked systematization or assessment (namely drugs with original studies characterizing specific ophthalmic ADRs but without causality assessment nor without meta-analysis). METHODS: S...


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