15 documents found, page 1 of 2
Metabolism-targeted therapy in NSCLC – A new theranostics inhalation approach u...
Mendes, Cindy; Martins, Filipa; Granja, Sara; Gonçalves, Joana; Barros, Hélio; Casimiro, Teresa; Ricardo, Ana Aguiar; Silva, Fernanda; Abreu, BrunaLung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer metabolic remodeling leads to excessive ROS production, triggering oxidative stress, promoting angiogenesis, causing cellular and ...
Biocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for cont...
Lopes, Mafalda; Restani, Rita; Carvalho, Marco António Paulo de; Correia, I.J.; Ricardo, Ana Aguiar; Bonifácio, VascoChitosan, a natural and abundant biopolymer has been long explored as a biocompatible material for the preparation of drug delivery devices. This strategy has been mostly accomplished using chemically crosslinked chitosan leading to more stable scaffolds. However, crosslinking has been shown to reduce both biocompatibility and swelling. In this work chitosan was crosslinked with novel biocompatible crosslinkers...
Aerosolizable gold nano-in-micro dry powder formulations for theragnosis and lu...
Silva, A. Sofia; Sousa, Ana M. L.; Cabral, Renato; Silva, Marta; Sequeira, Clarinda Costa; Miguel, Sónia; Bonifácio, Vasco; Casimiro, TeresaFunctionalized gold nanoparticles (AuNPs) have been widely investigated as promising multifunctional nanosystems for the theragnosis of lung cancer, the most common and prominent cause of cancer death worldwide. Nevertheless, nanoparticles are not in appropriate sizes for an accurate deep lung delivery and the lack of locally and effective delivery of therapeutic biomolecules to the deep lungs is, in fact, the ...
Nanogold POxylation: towards always-on fluorescent lung cancer targeting
Silva, A. Sofia; Silva, Marta; Miguel, Sónia P.; Bonifácio, Vasco; Correia, Ilídio Joaquim Sobreira; Ricardo, Ana AguiarGold nanoparticles (GNPs) are one of most investigated nanomaterials for lung cancer diagnosis and therapy (theragnosis). For imaging purposes, GNPs are often tagged with fluorescent probes, but unfortunately the associated plasmon resonance effect leads to fluorescence self-quenching, thus precluding accurate localization. In this study, biocompatible GNPs targeted with a laminin fragment were successfully eng...
Ibuprofen loaded PVA/chitosan membranes: A highly efficient strategy towards an...
Morgado, Patrícia I.; Miguel, Sónia P.; Correia, Ilídio Joaquim Sobreira; Ricardo, Ana AguiarDuring wound healing, an early inflammation can cause an increase of the wound size and the healing process can be considerably belated if a disproportionate inflammatory response occurs. (S)-ibuprofen (IBP), a non-steroidal anti-inflammatory agent, has been used for muscle healing and to treat venous leg ulcers, but its effect in skin wound healing has not been thoroughly studied thus far. Herein, IBP-β-cyclod...
Nano‐in‐Micro POxylated Polyurea Dendrimers and Chitosan Dry Powder Formulation...
Restani, Rita; Silva, A. Sofia; Pires, Rita; Cabral, Renato; Correia, Ilídio Joaquim Sobreira; Casimiro, Teresa; Bonifácio, Vasco; Ricardo, Ana AguiarPulmonary administration offers excellent advantages over conventional drug delivery routes, including increasing therapeutics bioavailability, and avoiding long‐term safety issues. Formulations of nano‐in‐micro dry powders for lung delivery are engineered using (S)‐ibuprofen as a model drug. These biodegradable formulations comprise nanoparticles of drug‐loaded POxylated polyurea dendrimers coated with chitosa...
Asymmetric membranes as ideal wound dressings: An overview on production method...
Morgado, Patrícia I.; Ricardo, Ana Aguiar; Correia, I.J.Healing a wound is a process that comprises sequential steps aimed to restore the structure and function of damaged cells and tissues. Since the antiquity, to promote an effective wound healing, different materials have been used to cover the wound. Nowadays, dressings that are able to mimic the structure and composition of skin are specifically designed to exhibit several required functions. To cope with this ...
Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging
Silva, A. Sofia; Bonifácio, Vasco; Raje, Vivek; Branco, Paula S.; Machado, Paulo Filipe Brito; Correia, Ilídio Joaquim Sobreira; Ricardo, Ana AguiarGold nanoparticles (AuNPs) are the most investigated nanomaterials for theragnosis applications. In a research field where live cell assays, as well as the tracking of nanomaterials into a cell's environment, are of extremely importance, water-soluble AuNPs have been intensively studied to overcome the toxic effects exerted by coatings. Unfortunately, AuNPs fluorescent tagging often fails due to self-quenching ...
Polyurea dendrimer for efficient cytosolic siRNA delivery
Restani, Rita; Conde, João; Baptista, Pedro; Cidade, Maria Teresa Varanda; Bragança, Ana; Morgado, Jorge; Correia, Ilídio Joaquim SobreiraThe design of small interfering RNA (siRNA) delivery materials showing efficacy in vivo is at the forefront of nanotherapeutics research. Polyurea (PURE-type) dendrimers are ‘smart’ biocompatible 3D polymers that unveil a dynamic and elegant back-folding mechanism involving hydrogen bonding between primary amines at the surface and tertiary amines and ureas at the core. Similarly, to a biological proton pump, t...
Poly(vinyl alcohol)/chitosan asymmetrical membranes: Highly controlled morpholo...
Morgado, Patrícia I.; Lisboa, Pedro; Ribeiro, MP.; Miguel, Sónia P.; Simões, Pedro; Correia, Ilídio Joaquim Sobreira; Ricardo, Ana AguiarAsymmetrical membranes have been reported as ideal wound dressings for skin regeneration. The usual methods (dry/wet-phase inversion) to produce those specific membranes are time consuming, and in majority of the cases demand the use of harmful organic solvents. In this study, supercritical carbon dioxide (scCO2)-assisted phase inversion method was applied to prepare poly(vinyl alcohol)/chitosan (PVA/CS) asymme...