5 documents found, page 1 of 1
Promising anticancer agents based on 8-hydroxyquinoline hydrazone copper(II) co...
Ribeiro, Nádia; Bulut, Ipek; Sergi, Baris; Pósa, Vivien; Spengler, Gabriella; Sciortino, Giuseppe; André, Vânia; Ferreira, Liliana P.; Biver, TaritaWe report the synthesis and characterization of a group of benzoylhydrazones (Ln) derived from 2-carbaldehyde-8-hydroxyquinoline and benzylhydrazides containing distinct para substituents (R = H, Cl, F, CH3, OCH3, OH and NH2, for L1-7, respectively; in L8 isonicotinohydrazide was used instead of benzylhydrazide). Cu(II) complexes were prepared by reaction of each benzoylhydrazone with Cu(II) acetate. All compou...
Solution chemical properties and anticancer potential of 8-hydroxyquinoline hyd...
Ribeiro, Nádia; Bulut, Ipek; Pósa, Vivien; Sergi, Baris; Sciortino, Giuseppe; Pessoa, João Costa; Maia, Luísa B.; Ugone, Valeria; Garribba, EugenioFunding Information: This work was supported by Centro de Química Estrutural, which is financed by national funds from Fundação para a Ciência e Tecnologia (FCT), projects LA/P/0056/2020, and Programa Operacional Regional de Lisboa 2020. The Portuguese NMR and Mass spectrometry IST-UL are acknowledged for the access to the equipment. This work was supported by the Portuguese-Hungarian Scientific & Technological...
Cu(II) and V(IV)O complexes with tri- or tetradentate ligands based on (2-hydro...
Ribeiro, Nádia; Bulut, İpek; Cevatemre, Buse; Teixeira, Carlos; Yildizhan, Yasemin; André, Vânia; Adão, Pedro; Pessoa, João; Acilan, CeydaFour new ligand precursors (H2L1–H2L4), derived from the Mannich condensation of two amino acids (L-Val and L-Phe) and two 3,5-disubstituted phenols (t-Bu or Me), and the corresponding oxidovanadium(IV) (1–4) and copper(II) (6–7) complexes are synthesized. Two other related compounds (H2L5 and H2L6), containing an additional 2-methyl-pyridine arm, and the corresponding VIVO (5) and CuII (8–9) complexes were als...
Experimental data on novel Fe(III)-complexes containing phenanthroline derivati...
Matos, Cristina P; Adiguzel, Zelal; Yildizhan, Yasemin; Cevatemre, Buse; Bagci-Onder, Tugba; Cevik, Ozge; Nunes, Patrique; Ferreira, Liliana P.This dataset is related to the research article entitled "May iron(III) complexes containing phenanthroline derivatives as ligands be prospective anticancer agents?" [1]. It includes the characterization by UV-Vis absorption spectroscopy and magnetic techniques of a group of mixed ligand Fe(III) complexes bearing a tripodal aminophenolate ligand L2-, H2L = N,N-bis(2-hydroxy-3,5-dimethylbenzyl)-N-(2-pyridylmethy...
May iron(III) complexes containing phenanthroline derivatives as ligands be pro...
Matos, Cristina P.; Adiguzel, Zelal; Yildizhan, Yasemin; Cevatemre, Buse; Onder, Tugba Bagci; Cevik, Ozge; Nunes, Patrique; Ferreira, Liliana P.Made available in DSpace on 2019-10-06T17:10:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-15; Fundação para a Ciência e a Tecnologia; We report the design, synthesis and biological studies on a group of mixed ligand Fe(III) complexes as anti-cancer drug candidates, namely their interaction with DNA, cytotoxicity and mechanism(s) of action. The aim is to obtain stable, efficient and selective Fe-...