5 documents found, page 1 of 1
Evaluation of the protective effect of MnTMPyP on the cytotoxicity induced by d...
Fernandes, Ana Sofia; Gaspar, Jorge; Cabral, M. Fatima; Bettencourt, Ana F.; Caneiras, Catla; Rueff, Jose; Castro, Matilde; Costa, Judite
Macrocyclic copper(II) complexes
Fernandes, Ana S.; Gaspar, Jorge; Cabral, M. Fatima; Caneiras, Catia; Guedes, Rita; Rueff, Jose; Castro, Matilde; Costa, Judite; Oliveira, Nuno G.Synthetic superoxide dismutase mimetics have emerged as a potential novel class of drugs for the treatment of oxidative stress related diseases. Among these agents, metal complexes with macrocyclic ligands constitute an important group. In this work we synthesized five macrocyclic copper(II) complexes and evaluated their ability to scavenge the superoxide anions generated by the xanthine-xanthine oxidase system...
Pyridine-containing macrocyclic copper(II) complexes
Fernandes, Ana S.; Oliveira, Nuno G.; Gaspar, Jorge; Cabral, M. Fatima; Caneiras, Catia; Rueff, Jose; Castro, Matilde; Costa, Judite
Properties of a new 4-imidazolyl derivative of a 14-membered tetraazamacrocycli...
Nunes, Rute M.; Delgado, Rita; Cabral, M. Fatima; Costa, Judite; Brandao, Paula; Felix, Vitor; Goodfellow, Brian J.A new bis-N,N'-(5-methylimidazol-4-ylmethyl) derivative of a 14-membered tetraazamacrocycle, L-1, has been synthesized. The protonation constants of this compound and the stability constants of its complexes with divalent first-row transition metal ions and Fe3+ were determined at 298.2 K in aqueous 0.10 mol dm(-3) KNO3. Compound L-1 exhibits high overall basicity, which is mainly conferred by theimidazolyl gro...
Novel copper(II) macrocyclic complexes with superoxide scavenging activity
Fernandes, Ana Sofia; Cabral, M. Fatima; Rueff, Jose; Caneiras, Catia; Gaspar, Jorge; Castro, Matilde; Costa, Judite; Oliveira, Nuno G.