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Association between cognitive reserve proxies and frailty phenotype: data from ...
Lorenzo-López, L; Cibeira, N; Hemadeh, A; López-López, R; Lema-Arranz, C; Maseda, A; Fernández-Bertólez, N; Costa, S; Pásaro, E; Valdiglesias, VA potential protective role of cognitive reserve proxies against frailty has been suggested in older adults. We explored the cross-sectional association between cognitive reserve indicators and frailty phenotype. Data were obtained from the UK Biobank. We included 31,975 dementia-free participants aged ≥ 60 years (50.7% females, 2.2% frail) who completed a web-based cognitive assessment (fluid intelligence, wor...
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty
Mohyuddin, H; Laffon, B; Teixeira, JP; Costa, S; Teixeira-Gomes, A; Pásaro, E; Constantine, N; Dagdag, A; Ortmeyer, HK; Tizenberg, B; Afram, L; Yen, PYBackground: Persistent inflammation related to aging (inflammaging) is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty.Methods: We analy...
Exploring Genetic Outcomes as Frailty Biomarkers
Valdiglesias, V; Sánchez-Flores, M; Marcos-Pérez, D; Lorenzo-López, L; Maseda, A; Millán-Calenti, JC; Pásaro, E; Laffon, BFrailty has emerged as a reliable measure of the aging process. Because the early detection of frailty is crucial to prevent or even revert it, the use of biomarkers would allow an earlier and more objective identification of frail individuals. To improve the understanding of the biological features associated with frailty as well as to explore different biomarkers for its early identification, several genetic ...