3 documents found, page 1 of 1
Plasma Metabolites Associated with OCT Features of Age-Related Macular Degenera...
Laíns, Inês; Han, Xikun; Gil, João; Providência, Joana; Nigalye, Archana; Alvarez, Rodrigo; Douglas, Vivian Paraskevi; Mendez, Kevin; Katz, RavivPurpose: The most widely used classifications of age-related macular degeneration (AMD) and its severity stages still rely on color fundus photographs (CFPs). However, AMD has a wide phenotypic variability that remains poorly understood and is better characterized by OCT. We and others have shown that patients with AMD have a distinct plasma metabolomic profile compared with controls. However, all studies to da...
Human Plasma Metabolomics in Age-Related Macular Degeneration: Meta-Analysis of...
Laíns, Inês; Chung, Wonil; Kelly, Rachel S.; Gil, João; Marques, Marco; Barreto, Patrícia; Murta, Joaquim N.; Kim, Ivana K.; Vavvas, Demetrios G.The pathogenesis of age-related macular degeneration (AMD), a leading cause of blindness worldwide, remains only partially understood. This has led to the current lack of accessible and reliable biofluid biomarkers for diagnosis and prognosis, and absence of treatments for dry AMD. This study aimed to assess the plasma metabolomic profiles of AMD and its severity stages with the ultimate goal of contributing to...
Diabetic Choroidopathy: Choroidal Vascular Density and Volume in Diabetic Retin...
Wang, Jay C.; Laíns, Inês; Providência, Joana; Armstrong, Grayson W.; B M Santos, Ana Rita; Gil, Pedro; Gil, João; Talcott, Katherine E.Purpose To compare choroidal vascular density (CVD) and volume (CVV) in diabetic eyes and controls, using en face swept-source optical coherence tomography (SS-OCT). Design Prospective cross-sectional study. Methods Setting: Multicenter. Patient Population: Total of 143 diabetic eyes—27 with no diabetic retinopathy (DR), 47 with nonproliferative DR (NPDR), 51 with NPDR and diabetic macular edema (DME), and 18 w...