2 documents found, page 1 of 1
Dissection of the pre-germinal center B-cell maturation pathway in common varia...
del Pino-Molina, Lucía; López-Granados, Eduardo; Lecrevisse, Quentin; Torres Canizales, Juan; Pérez-Andrés, Martín; Blanco, Elena; Wentink, MarjoleinIntroduction: Common Variable Immunodeficiency (CVID) is characterized by defective antibody production and hypogammaglobulinemia. Flow cytometry immunophenotyping of blood lymphocytes has become of great relevance for the diagnosis and classification of CVID, due to an impaired differentiation of mature post-germinal-center (GC) class-switched memory B-cells (MBC) and severely decreased plasmablast/plasma cell...
Managing Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable...
van de Ven, Annick A. J. M.; Alfaro, Tiago M.; Robinson, Alexandra; Baumann, Ulrich; Bergeron, Anne; Burns, Siobhan O.; Condliffe, Alison M.Background: Granulomatous–lymphocytic interstitial lung disease (GLILD) is a rare, potentially severe pulmonary complication of common variable immunodeficiency disorders (CVID). Informative clinical trials and consensus on management are lacking. Aims: The European GLILD network (e-GLILDnet) aims to describe how GLILD is currently managed in clinical practice and to determine the main uncertainties and unmet n...