246 documents found, page 1 of 25
Applications and properties of PDMS: from biomicrofluidics to transparent face ...
Lima, Rui Alberto Madeira Macedo; Maia, Renata Faria; Souza, Andrews Victor Almeida; Barbosa, Filipe; Carvalho, Denise Andreia Mota[Excerpt] Introduction Many researchers have studied elastomers owing to their outstanding biomechanical properties, including !exibility and chemical stability. Among the different elastomers on the market, polydimethylsiloxane (PDMS) has recently gained prominence (Miranda et al., 2022). This material has been used in a variety of industrial applications, including mechanics, electronics, and biomedicine. Som...
Polydimethylsiloxane surface modification for microfluidic devices and organ-on...
Gonçalves, Inês Maia Silva Rodrigo; Gonçalves, Margarida; Pinho, Diana; Cardoso, Beatriz Dias; Sousa, Patrícia C.; Zille, Andrea; Hori, TakeshiOne of the most popular materials for creating bio models and microfluidic devices is polydimethylsiloxane (PDMS). Recently, a unique class of devices called organs-on-a-chip (OoC) was created by fusing cell cultures with microfluidic devices. To make it easier to investigate both healthy and pathological conditions, these devices replicate the micro physiological characteristics of the human body. OoCs are mos...
A portable and low-cost optical device for pigment-based taxonomic classificati...
Magalhães, Vitor; Pinto, Vânia Cristina Gonçalves; Sousa, Paulo Jorge Teixeira; Afonso, José A.; Gonçalves, L. M.; Fernández, Emilio; Minas, GraçaThe proliferation of certain phytoplankton species may lead to harmful algal blooms (HABs) that can affect living resources and human health. Therefore, an accurate identification of phytoplankton populations is essential for the sustainable management of some activities relevant for the blue economy, such as aquaculture, being also relevant for environmental monitoring and marine research purposes. Microalgae ...
A proof-of-concept study aiming for the integration of an optical biosensor in ...
Correia, Margarida O.; Sousa, Paulo Jorge Teixeira; Rodrigues, Raquel Oliveira; Minas, GraçaAlzheimer’s disease (AD), a progressive neurodegenerative disorder, is marked by the abnormal production of amyloid-beta (Aβ) fibrils, a key biomarker for diagnosis and illness monitoring. Advanced microfluidic devices, such as brain-on-a-chip (BoC), are innovative preclinical tools with the potential to revolutionize AD early diagnosis and treatment. However, existing BoCs face limitations, including challenge...
Modeling microgravity using clinorotation in a microfluidic environment: a nume...
Fernandes, João; Machado, Dara; Minas, Graça; Catarino, Susana Oliveira; Pinho, DianaMicrogravity simulation is essential for studying particle dynamics in space-related applications where traditional gravitational effects are absent. This study presents a numerical investigation of particle behavior in a clinostat-driven microfluidic channel, aiming to simulate microgravity conditions. A computational model was developed in COMSOL Multiphysics to analyze the impact of channel size, particle di...
Modelling the heat distribution in organ-on-a-chip systems using integrated mic...
Ferreira, Gabriel Malheiro; Sousa, Patrícia C.; Catarino, Susana Oliveira; Minas, Graça[Excerpt] Microfluidic systems with integrated heating transducers are of growing interest for applications in biochemical sensing, lab-on-a-chip and organ-on-a-chip (OoC) technologies [1]. Particularly, in OoC systems, temperature monitoring is crucial to maintain the cultured cells in a well-defined microenvironment for proper growth [2]. This monitoring can be achieved through temperature control systems com...
Optical sensor system to monitor the pH of circulating media on biomimetic micr...
Mendes, Fernando; Miranda, Inês Sofia Ferreira; Rodrigues, Raquel Oliveira; Ferreira, Gabriel Malheiro; Schütte, Helmut; Gassmann, StefanpH is a physiological parameter of great importance in biomedical research. For example, during cell growth process, pH is usually lowered due to the acidic metabolites released by the cells. This decrease on the pH value can affect biological processes and, consequently, affect the accuracy of the research. To monitor the pH changes along cell engineering experiments, cell culture media is usually complemented...
Evaluating the response of malaria-infected RBCs to magnetic nanocarriers under...
Ferreira, Margarida Gomes; Freitas, Bruno José Ferreira; Baptista, Vitória Cunha; Pinho, Diana; Minas, Graça; Veiga, Maria IsabelMalaria still affects millions of people each year, posing a persistent public health challenge. One major hurdle is the increasing resistance of malaria parasite, Plasmodium falciparum, to the current therapeutic drugs, which calls for alternative treatment strategies. This work takes a first step in exploring whether targeted drug delivery systems using nanocarriers can provide a promising solution to mitigat...
Design and numerical optimization of a lab-on-a-chip device for blood cells’ an...
Fadlelmoula, Ahmed; Carvalho, Vítor; Minas, Graça; Catarino, Susana OliveiraThe blood circulation carries valuable information about the human body's functioning. Thus, there is a continuous need for novel, accurate, and fast techniques to analyse blood samples. The objective of this research is to design, numerically simulate and optimize a low-cost microfluidic lab-on-a-chip device, which, in the future, can be used to quickly help the diagnosis of different diseases, by using a sing...
Development of a photoacoustic acquisition system and their proof-of-concept fo...
Pinheiro, Bruna Regina Madureira; Pinto, Vânia Cristina Gonçalves; Dinis, Hugo Daniel Costa; Belsley, M.; Catarino, Susana Oliveira; Minas, GraçaRecently, Organ-on-a-Chip (OoC) platforms have arisen as an increasingly relevant experimental tool for successfully replicating human physiology and disease. However, there is a lack of a standard technology to monitor the OoC parameters, especially in a non-invasive and label-free way. Photoacoustic (PA) systems can be considered an alternative and accurate assessment method for OoC platforms. PA systems comb...