242 documents found, page 1 of 25
A portable and low-cost optical device for pigment-based taxonomic classificati...
Magalhães, Vitor; Pinto, Vânia Cristina Gonçalves; Sousa, Paulo Jorge Teixeira; Afonso, José A.; Gonçalves, L. M.; Fernández, Emilio; Minas, GraçaThe proliferation of certain phytoplankton species may lead to harmful algal blooms (HABs) that can affect living resources and human health. Therefore, an accurate identification of phytoplankton populations is essential for the sustainable management of some activities relevant for the blue economy, such as aquaculture, being also relevant for environmental monitoring and marine research purposes. Microalgae ...
Design and numerical optimization of a lab-on-a-chip device for blood cells’ an...
Fadlelmoula, Ahmed; Carvalho, Vítor; Minas, Graça; Catarino, Susana OliveiraThe blood circulation carries valuable information about the human body's functioning. Thus, there is a continuous need for novel, accurate, and fast techniques to analyse blood samples. The objective of this research is to design, numerically simulate and optimize a low-cost microfluidic lab-on-a-chip device, which, in the future, can be used to quickly help the diagnosis of different diseases, by using a sing...
A proof-of-concept study aiming for the integration of an optical biosensor in ...
Correia, Margarida O.; Sousa, Paulo Jorge Teixeira; Rodrigues, Raquel Oliveira; Minas, GraçaAlzheimer’s disease (AD), a progressive neurodegenerative disorder, is marked by the abnormal production of amyloid-beta (Aβ) fibrils, a key biomarker for diagnosis and illness monitoring. Advanced microfluidic devices, such as brain-on-a-chip (BoC), are innovative preclinical tools with the potential to revolutionize AD early diagnosis and treatment. However, existing BoCs face limitations, including challenge...
Modeling microgravity using clinorotation in a microfluidic environment: a nume...
Fernandes, João; Machado, Dara; Minas, Graça; Catarino, Susana Oliveira; Pinho, DianaMicrogravity simulation is essential for studying particle dynamics in space-related applications where traditional gravitational effects are absent. This study presents a numerical investigation of particle behavior in a clinostat-driven microfluidic channel, aiming to simulate microgravity conditions. A computational model was developed in COMSOL Multiphysics to analyze the impact of channel size, particle di...
Low-cost photoacoustic system for biomedical applications
Ferreira, João Filipe SObreiro; Pinto, Vânia Cristina Gonçalves; Matos, Tiago; Catarino, Susana Oliveira; Minas, Graça; Sousa, Paulo Jorge TeixeiraRecently, the field of photoacoustic (PA) imaging has garnered significant attention due to its ability to provide high-resolution images and real-time monitoring of biological tissues. However, PA systems have relied on expensive and complex laser sources and detection mechanisms, limiting their accessibility for widespread use in both clinical and research settings. So, this work aims to address these limitat...
Numerical and experimental analysis of mixing efficiency in passive micromixers...
Ferreira, Filipe Maurício Santos; Sousa, Paulo Jorge Teixeira; Minas, Graça; Lima, Rui Alberto Madeira Macedo; Pinto, Vânia Cristina GonçalvesPassive micromixers play a critical role in microfluidic applications, particularly in lab-on-a-chip devices, since they do not require external energy input, being simpler, cheaper and portable. This paper reports the mixing efficiency by numerical simulation (using COMSOL Multiphysics) and by experimental validation of two 2D polydimethylsiloxane micromixer geometries. The tested flow rate ratios, 1:1, 1:4 an...
Optimizing acoustic pressure fields in SAW microfluidic devices: A numerical st...
Amorim, Débora; Dinis, Hugo Daniel Costa; Minas, Graça; Sousa, Patrícia C.; Abreu, Carlos; Catarino, Susana OliveiraSurface acoustic wave-based microfluidic devices have gained substantial attention for their effectiveness in manipulating, detecting, and quantifying biological samples. These systems utilize interdigitated transducers deposited on piezoelectric substrates to generate acoustic fields within microchannels. This study presents a comparative analysis of acoustic pressure fields generated using different piezoelec...
Synthetic data generation using machine learning algorithms for enhanced Type 2...
Fadlelmoula, Ahmed; Torres, Helena; Catarino, Susana Oliveira; Minas, Graça; Carvalho, VitorStrict privacy regulations in healthcare limit access to patient data for research and predictive modeling. To address this, the study explores synthetic data as a privacy-preserving alternative that also enhances dataset size and diversity. Using machine learning-based generative models, Generative Adversarial Networks (GANs) and Autoencoders (AEs) the researchers created synthetic tabular data to improve type...
Recent advances and perspectives of MicroNeedles for biomedical applications
Maia, Renata Faria; Machado, Pedro; Rodrigues, Raquel Oliveira; Faustino, Vera Luísa Carreira; Schütte, Helmut; Gassmann, Stefan; Lima, Rui A.Microneedles (MN) technology has emerged as a transformative tool within the biomedical field, offering innovative solutions to challenges in drug delivery, diagnostics, and therapeutic applications. This review article provides an in-depth exploration of the diverse perspectives and applications of MNs, shedding light on their pivotal role in shaping the future of biomedical research and clinical practice. It ...
Modelling the heat distribution in organ-on-a-chip systems using integrated mic...
Ferreira, Gabriel Malheiro; Sousa, Patrícia C.; Catarino, Susana Oliveira; Minas, Graça[Excerpt] Microfluidic systems with integrated heating transducers are of growing interest for applications in biochemical sensing, lab-on-a-chip and organ-on-a-chip (OoC) technologies [1]. Particularly, in OoC systems, temperature monitoring is crucial to maintain the cultured cells in a well-defined microenvironment for proper growth [2]. This monitoring can be achieved through temperature control systems com...