3 documents found, page 1 of 1
Chemical Composition and Cytotoxic Activity of the Root Essential Oil from Jatr...
Silva,Celia E. L. da; Minguzzi,Sandro; Silva,Rogério C. L. da; Matos,Maria F. C.; Tofoli,Danilo; Carvalho,João E. de; Ruiz,Ana L. T. G.The essential oil of roots of Jatropha ribifolia, obtained by hydrodistillation, was characterized in terms of its chemical composition by chromatographic method with flame ionization detection (GC-FID) and gas chromatography coupled to electron ionization mass spectrometry (GC-MS). The analyses and identification pointed by mass fragmentation pattern and retention index revealed the presence of 49 compounds, r...
Isolation, structural identification and cytotoxic activity of hexanic extract,...
Fernandes,Elaine de S.; Rodrigues,Fátima A.; Tófoli,Danilo; Imamura,Paulo M.; Carvalho,João E. de; Ruiz,Ana L. T. G.; Foglio,Mary A.; Minguzzi,SandroThe cytotoxicity of a hexanic fraction produced from the ethanolic crude extract, obtained from Jatropha ribifolia (Pohl) Baill, Euphorbiaceae, roots was evaluated against ten human cancer cell lines (MCF-7, NCI-ADR/RES, OVCAR-3, PC-3, HT-29, NCI-H460,786-O, UACC-62, K-562, U251) compared with doxorrubicine as positive control. Compounds jatrophone and cyperenoic acid were isolated from the hexanic extract and ...
Derivados citotóxicos de vitanolidos isolados das folhas de Acnistus arborescens
Minguzzi,Sandro; Barata,Lauro E. S.; Cordell,Geoffrey A.In view of anticancer activity of 7 β-acetoxywithanolide D (2) and 7β-16α-diacetoxywithonide D (3), isolated from the leaves of Acnistus arborescens (Solanaceae), five withanolide derivatives were obtained and their structures were determined by NMR, MS and IV data analysis. The in vitro anticancer activity of these derivatives was evaluated in a panel of cancer cell lines: human breast (BC-1), human lung (Lu1)...