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Characterization of technical skill progress in a standardized rabbit model for...

Etlinger, P; Barroso, C; Miranda, A; Moreira Pinto, J; Lamas-Pinheiro, R; Ferreira, H; Leão, P; Kovács, T; Juhász, L; Sasi Szabó, L; Farkas, A; Vajda, P

Background: Laboratory skills training is an essential step before conducting minimally invasive surgery in clinical practice. Our main aim was to develop an animal model for training in clinically highly challenging laparoscopic duodenal atresia repair that could be useful in establishing a minimum number of repetitions to indicate safe performance of similar interventions on humans. Materials and methods: A r...


Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVI...

Freitas, AT; Calhau, C; Antunes, G; Araújo, B; Bandeira, M; Barreira, S; Bazenga, F; Braz, S; Caldeira, D; Santos, SCR; Faria, A; Faria, D; Fraga, M

Vitamin D is a fundamental regulator of host defences by activating genes related to innate and adaptive immunity. Previous research shows a correlation between the levels of vitamin D in patients infected with SARS-CoV-2 and the degree of disease severity. This work investigates the impact of the genetic background related to vitamin D pathways on COVID-19 severity. For the first time, the Portuguese populatio...


How to resume elective orthopaedic surgical procedures during the COVID-19 pand...

Diogo, N; Miranda, A; Ruano, A; Mendes, E; Mendes, F; Montes, J; Alves, J; Rosa, I; Alegrete, N; Neves, N; Lourenço, P; Felicíssimo, P; Sá Cardoso, P

This document was prepared by the College of Orthopedics of the Portuguese Medical Association with the aim of developing the guidelines on the resumption of elective surgical activity in Orthopedics during the COVID-19 pandemic. It sets the criteria that allow the prioritization of surgeries according to the severity of the clinical situation, based on existing and published classifications. Moreover, it provi...


Emergence of Multidrug-Resistant Mycobacterium Tuberculosis of the Beijing Line...

Perdigão, J; Silva, C; Maltez, F; Machado, D; Miranda, A; Couto, I; Rabna, P; Florez de Sessions, P; Phelan, J; Pain, A; McNerney, R; Hibberd, M

The Beijing genotype comprises a highly disseminated strain type that is frequently associated with multidrug resistant (MDR) tuberculosis (TB) and increased transmissibility but, countries such as Portugal and Guinea-Bissau fall outside the regions phylogeographically associated with this specific genotype. Nevertheless, recent data shows that this genotype might be gradually emerging in these two countries as...


Como Retomar a Atividade Cirúrgica Eletiva em Ortopedia Durante a Pandemia COVI...

Diogo, N; Miranda, A; Ruano, A; Mendes, E; Mendes, F; Montes, J; Alves, J; Rosa, I; Alegrete, N; Neves, N; Lourenço, P; Felicíssimo, P; Sá Cardoso, P

Este documento foi elaborado pelo Colégio de Ortopedia da Ordem dos Médicos com o objetivo de estabelecer as orientações sobre a retoma da atividade cirúrgica programada em Ortopedia durante a pandemia COVID-19. As presentes normas de orientação: a) definem os critérios que permitem a priorização das cirurgias de acordo com a gravidade da situação clínica, com base em classificações existentes e publicadas; b) ...


COARSE FACE, HYPOTONIA, AND NEURODEVELOPMENTAL REGRESSION

Miranda, A; Ezequiel, M; Luis, C; DupontI, J; GasparII, P; Vilarinho, L, et al.

Inborn errors of metabolism are a heterogeneous class of multisystemic diseases which, although individually rare, are collectively quite common. Central nervous system is usually affected. The authors report the case of a five-month-old girl, daughter of non-consanguineous parents, born after an unremarkable full-term pregnancy and delivery. Hypotonia and neurodevelopmental regression were noted from the age o...


Using Genomics to Understand the Origin and Dispersion of Multidrug and Extensi...

Perdigão, J; Gomes, P; Miranda, A; Maltez, F; Machado, D; Silva, C; Phelan, J; Brum, L; Campino, S; Couto, I; Viveiros, M; Clark, T; Portugal, I

Portugal is a low incidence country for tuberculosis (TB) disease. Now figuring among TB low incidence countries, it has since the 1990s reported multidrug resistant and extensively drug resistant (XDR) TB cases, driven predominantly by two strain-types: Lisboa3 and Q1. This study describes the largest characterization of the evolutionary trajectory of M/XDR-TB strains in Portugal, spanning a time-period of two...


Diabetes Policies and Pharmacy- -based Diabetes Interventions in Portugal: A Co...

Costa, S; Horta, MR; Santos, R; Mendes, Z; Jacinto, I; Guerreiro, J; Cary, M; Miranda, A; ., Helling; Martins, AP

BackgroundPharmacy-based interventions are complex public health endeavors which include, but are not restricted to, the conventional medication supply role. In diabetes, such interventions may improve patients’ outcomes. The aim of this study was to review relevant policies and research developed in Portugal directed at pharmacy-based diabetes interventions, and to inform future policies, practice and research...



Persistent radiologic thoracic hypotransparency: A case report and review of th...

Miranda, A; Marques, J; Ferreira, J; Cunha, F; Ribeiro, M; Ruivo, R

A thymolipoma is a slow-growing, anterior mediastinal tumor, rare in childhood. The authors present a report of a 4-year-old girl with persistent right thoracic hypotransparency on the chest radiograph. Computed tomography and magnetic resonance imaging revealed an anterior, well-limited, mediastinal mass of heterogeneous density, with lipomatous and soft tissue density areas. The tumor was totally excised and ...


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