18 documents found, page 1 of 2
NiTi laser textured implants with improved in vivo osseointegration: an experim...
Costa, M.M.; Miranda, A.; Bartolomeu, F.; Carvalho, O.; Matos, S.; Miranda, Georgina; Silva, F.S.Laser surface texturing is a versatile approach for manufacturing implants with suitable surfaces for osseointegration. This work explores the use of laser to fabricate NiTi textured implants, testing two different groove-based designs. Their performance was evaluated in vivo through implantation in Sprague Dawley rats’ femur, being then analyzed after 4 and 12 weeks of implantation. Push-out experiments and hi...
Educar para a saúde laboral: perceção da qualidade de vida em relação a variáve...
Moreira, S.; Miranda, A.; Lima, C.; Gonçalves, C.; Mesquita, Cristina; Lopes, Sofia; Machado, J.; Santos, Paula ClaraOs trabalhadores de escritório permanecem em posições estacionárias durante longos períodos e estão sujeitos a elevadas cargas laborais que podem interferir com a Qualidade de Vida, em interação com caraterísticas do trabalhador (como personalidade, autonomia, competência e empenho no trabalho). A Qualidade de Vida é um conceito multidimensional influenciado por fatores sociodemográficos, de saúde e trabalho, q...
Non-AIDS-related comorbidities in people living with HIV-1 aged 50 years and ol...
Serrão, R.; Piñero, C.; Velez, J.; Coutinho, D.; Maltez, F.; Lino, S.; Sarmento E Castro, R.; Tavares, A.; Pacheco, P.; Lopes, M.; Mansinho, K.Objective: To characterize the profile of non-AIDS-related comorbidities (NARC) in the older HIV-1-infected population and to explore the factors associated with multiple NARC. Methods: This was a multicentre, cross-sectional study including HIV-1-infected patients aged ≥50 years, who were virologically suppressed and had been on a stable antiretroviral therapy (ART) regimen for at least 6 months. A multiple re...
Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulatin...
Costa, M.M.; Lima, R.; Melo-Fonseca, F.; Bartolomeu, F.; Alves, N.; Miranda, A.; Gasik, M.; Silva, F.S.; Silva, N.A.; Miranda, G.Load-bearing implants success is strongly dependent on several physical and chemical properties that are known to drive cellular response. In this work, multi-material β-TCP-Ti6Al4V cellular structures were designed to combine Ti6Al4V mechanical properties and β-Tricalcium Phosphate bioactivity, in order to promote bone ingrowth as the bioactive material is being absorbed and replaced by newly formed bone. In t...
45S5 BAG-Ti6Al4V structures: The influence of the design on some of the physica...
Melo-Fonseca, F.; Lima, R.; Costa, M.M.; Bartolomeu, F.; Alves, Nuno; Miranda, A.; Gasik, M.; Silva, F.S.; Silva, N.A.; Miranda, G.Multi-material Ti6Al4V cellular structures impregnated with 45S5 bioactive glass were designed and produced using Selective LaserMelting (SLM), an additive manufacturing technique, combinedwith Press and Sintering focusing on load bearing components like hip implants. These structures were designed to combine Ti6Al4V mechanical properties and promote bone ingrowth into the structure as the bioactive material (4...
Differential impact of chronic stress along the hippocampal dorsal–ventral axis
Pinto, Vítor; Costa, João Carlos Cardoso; Morgado, Pedro; Mota, Cristina de Fátima Sousa da; Miranda, A.; Bravo, Ana Francisca Rodrigues VazStress impacts differently in distinct brain regions. However, so far few studies have focused on the differential responses triggered by stressful stimuli on the intrinsic functional heterogeneity of the hippocampal axis. In this study, we assessed the functional and structural alterations caused by exposure to a chronic unpredictable stress (CUS) paradigm on the dorsal-ventral axis of the hippocampus. The mor...
Design and fabrication of SiO2/TiO2 and MgO/TiO2 based high selective optical f...
Pimenta, Sara; Cardoso, S.; Miranda, A.; De Beule, P.; Castanheira, Elisabete M. S.; Minas, GraçaThis paper presents the design, optimization and fabrication of 16 MgO/TiO2 and SiO2/TiO2 based high selective narrow bandpass optical filters. Their performance to extract diffuse reflectance and fluorescence signals from gastrointestinal tissue phantoms was successfully evaluated. The obtained results prove their feasibility to correctly extract those spectroscopic signals, through a Spearman’s rank correlati...
Reconstrução da pálpebra superior com retalho de Cutler-Beard modificado
Melo Cardoso, A.; Goulão, J.; Cardoso, J.; Marques, N.; Miranda, A.; Pereira, M.; Campos, N.Objectivo: O retalho de Cutler-Beard (ou retalho em ponte)1 é uma técnica usada habitualmente para reconstruir grandes defeitos da pálpebra superior (envolvimento ≥ 75%). A retração palpe- bral e o entrópio representam complicações comuns. Para evitar esses problemas, os autores modificaram o procedimento originalmente descrito por Cutler-Beard1 com colocação de um enxerto de cartilagem. Métodos: Est...
Ptose Congénita: da Clínica ao Tratamento
Melo Cardoso, A.; Cardoso, J.; Marques, N.; Miranda, A.; Pereira, M.; Fonseca, T.; Campos, N.A ptose congénita está habitualmente presente desde o nascimento ou é diagnosticada durante o primeiro ano de vida. Consiste numa diminuição vertical da abertura palpebral por descida da pálpebra superior. A sua etiologia ainda não está bem esclarecida, mas prevalece a hipótese neurológica como a mais provável. Pode ocorrer de forma isolada ou como parte de outros sín- dromes oculares ou patologias sistémicas. ...
HIV-2 integrase polymorphisms and longitudinal genotypic analysis of HIV-2 infe...
Cavaco-Silva, J.; Abecasis, A.; Miranda, A.; Poças, J.; Narciso, J.; Águas, M.; Maltez, F.; Almeida, I.; Germano, I.; Diniz, A.; Gonçalves, M.To characterize the HIV-2 integrase gene polymorphisms and the pathways to resistance of HIV-2 patients failing a raltegravir-containing regimen, we studied 63 integrase strand transfer inhibitors (INSTI)-naïve patients, and 10 heavily pretreated patients exhibiting virological failure while receiving a salvage raltegravir-containing regimen. All patients were infected by HIV-2 group A. 61.4% of the integrase r...