15 documents found, page 1 of 2
Diaphragmatic hernia repair porcine model to compare the performance of biodegr...
Scuglia, Marianna; Frazão, Laura P.; Miranda, Alice Augusta Macedo; Martins, Albino; Barbosa-Sequeira, Joana; Coimbra, Diana; Longatto, AdhemarBackground Patch repair of congenital diaphragmatic hernia (CDH) using Gore-Tex® is associated with infection, adhesions, hernia recurrence, long-term musculoskeletal sequels and poor tissue regeneration. To overcome these limitations, the performance of two novel biodegradable membranes was tested to repair CDH in a growing pig model. Methods Twelve male pigs were randomly assigned to 3 diferent groups of 4 an...
NiTi laser textured implants with improved in vivo osseointegration: an experim...
Costa, M. M.; Miranda, Alice Augusta Macedo; Bartolomeu, Flávio; Carvalho, Óscar Samuel Novais; Matos, S.; Miranda, G.; Silva, Filipe SamuelLaser surface texturing is a versatile approach for manufacturing implants with suitable surfaces for os-seointegration. This work explores the use of laser to fabricate NiTi textured implants, testing two dif-ferent groove-based designs. Their performance was evaluated in vivo through implantation in Sprague Dawley rats' femur, being then analyzed after 4 and 12 weeks of implantation. Push-out experiments and ...
Differentiation between normal and tumor mammary glands with depth-resolved att...
Maciel, Marino Jesus Correia; Pereira, Hugo Martins; Pimenta, Sara Filomena Ribeiro; Miranda, Alice Augusta Macedo; Nunes-Pereira, Eduardo J.Optical coherence tomography (OCT) is a well-established imaging technology for high-resolution, cross-sectional imaging of biological tissues. Imaging processing and light attenuation coefficient estimation allows to further improve the OCT diagnostic capability. In this paper we use a commercial OCT system, Telesto II-1325LR from Thorlabs, and demonstrate its ability to differentiate normal and tumor mammary ...
Raman spectroscopy for tumor diagnosis in mammary tissue
Pimenta, Sara Filomena Ribeiro; Maciel, Marino Jesus Correia; Miranda, Alice Augusta Macedo; Cerqueira, M. F.; Alpuim, P.; Correia, J. H.This paper demonstrates the potential of Raman spectroscopy in the ex-vivo analysis of resected normal and tumor mammary mouse glands, using a commercial confocal Raman microscope. The Raman spectra were acquired with a 785 nm excitation laser at 40 mW and using an integration time of 2 s. The Raman spectra for normal and tumor mouse mammary glands are presented and compared with literature results. The Raman s...
Development of β-TCP-Ti6Al4V structures: driving cellular response by modulatin...
Costa, M. M.; Lima, Rui Augusto Ribeiro; Fonseca, Francisca Rocha Melo; Bartolomeu, Flávio; Alves, N.; Miranda, Alice Augusta Macedo; Gasik, M.Load-bearing implants success is strongly dependent on several physical and chemical properties that are known to drive cellular response. In this work, multi-material β-TCP-Ti6Al4V cellular structures were designed to combine Ti6Al4V mechanical properties and β-Tricalcium Phosphate bioactivity, in order to promote bone ingrowth as the bioactive material is being absorbed and replaced by newly formed bone. In t...
45S5 BAG-Ti6A14V structures: The influence of the design on some of the physica...
Fonseca, Francisca Rocha Melo; Lima, R.; Costa, M. M.; Bartolomeu, F.; Alves, N. M. Fernandes; Miranda, Alice Augusta Macedo; Gasik, M.Multi-material Ti6Al4V cellular structures impregnated with 45S5 bioactive glass were designed and produced using Selective Laser Melting (SLM), an additive manufacturing technique, combined with Press and Sintering focusing on load bearing components like hip implants. These structures were designed to combine Ti6Al4V mechanical properties and promote bone ingrowth into the structure as the bioactive material ...
Inflammatory response and long-term behavioral assessment after neonatal CO2-pn...
Miranda, Alice Augusta Macedo; Roque, Susana; Miranda, Cláudia Sofia Serre; Pêgo, José M.; Correia-Pinto, JorgeBackground: Carbon-dioxide (CO2)-pneumothorax during minimally invasive surgery induces well-known metabolic changes. However, little is known about its impact on the central nervous system.The aim of this work is to evaluate the acute impact of CO2-pneumothorax over central cytokine response and its long-term effect on animal behavior.Methods: This is an experimental study where neonatal Sprague-Dawley rats ar...
Studies on thoracic and peritoneal CO2-insufflation in neonatal rats: 2 implica...
Miranda, Alice Augusta MacedoMinimally invasive surgery (MIS) has been increasingly used and the continuous development of technology and instruments allowed the application of this surgical approach, not only in adults, but also in paediatric and neonatal patients to correct several birth defects. Since the beginning of its application in adult patients, several studies on the hemodynamic, metabolic and inflammatory changes during MIS are...
Neurodevelopment impact of CO2-pneumoperitoneum in neonates: experimental study...
Miranda, Alice Augusta Macedo; Roque, Susana; Pêgo, José M.; Correia-Pinto, JorgeLaparoscopy is becoming more common in neonates. However, concerns remain about the impact of the carbon-dioxide (CO2)-insufflation over the neonatal brain. We aim to evaluate the peripheral (serum) and central (cerebrospinal fluid [CSF]) cytokine response after neonatal CO2-pneumoperitoneum and its impact over neurodevelopmental milestones acquisition and long-term behavioral outcomes.
A dual-modal CT/US kidney phantom model for image-guided percutaneous renal access
Fonseca, João Luís Gomes; Miranda, Alice Augusta Macedo; Morais, Pedro; Queirós, Sandro Filipe Monteiro; Pinho, A. C. Marques; Fonseca, Jaime C.Percutaneous renal access (PRA) is a crucial step in some minimally invasive kidney interventions. During this step, the surgeon inserts a needle through the skin until the kidney target site using fluoroscopy and ultrasound imaging. Recently, new concepts of enhanced image-guided interventions have been introduced in these interventions. However, their validation remains a challenging task. Phantom models have...