16 documents found, page 1 of 2
Sodium alginate-based multifunctional sandwich-like system for treating wound i...
Ribeiro, Ana R. M.; Teixeira, Marta O.; Ribeiro, Lara; Tavares, Tânia Daniela Eugénio; Miranda, Catarina S.; Costa, André F.; Ribeiro, ArturMicrobial colonization and development of infections in wounds is a sign of chronicity. The prevailing approach to manage and treat these wounds involves dressings. However, these often fail in effectively addressing infections, as they struggle to both absorb exudates and maintain optimal local moisture. The system here presented was conceptualized with a three-layer design: the outer layer made of a fibrous p...
Antimicrobial, antioxidant and cytocompatible coaxial wet-spun fibers made of p...
Miranda, Catarina S.; Marinho, Elina Margarida Ribeiro; Seabra, Catarina Leal; Evenou, Camille; Lamartine, Jérôme; Fromy, Berengere; Costa, Susana P. G.Chronic wounds represent a serious worldwide concern, being often associated with bacterial infections. As the prevalence of bacterial infections increase, it is crucial to search for alternatives. Essential oils (EOs) constitute a promising option to antibiotics due to their strong anti-inflammatory, analgesic, antioxidant and antibacterial properties. However, such compounds present high volatility. To addres...
Inhibition of enzyme and bacteria activities in diabetic ulcer-like scenarios v...
Ribeiro, Ana R. M.; Miranda, Catarina S.; Silva, Ana Francisca G.; Mendes, Filipa D. P.; Silva, Beatriz M.; Oliveira, Bruna A. S.; Paiva, Eduardo D.In diabetic ulcers, an increased secretion of human neutrophil elastase (HNE) and bacterial infections play crucial roles in hindering healing. Considering that, the present study proposed the development of multi-action polycaprolactone (PCL)/polyethylene glycol (PEG) electrospun fibers incorporating elastase-targeting peptides, AAPV and WAAPV, via blending. Characterization confirmed WAAPV’s efficacy in regul...
Sodium alginate/polycaprolactone co-axial wet-spun microfibers modified with N-...
Miranda, Catarina S.; Silva, A. Francisca G.; Seabra, Catarina L.; Reis, Salette; Silva, Maria Manuela; Pereira-Lima, Sílvia M. M. A.In chronic wound (CW) scenarios, Staphylococcus aureus-induced infections are very prevalent. This leads to abnormal inflammatory processes, in which proteolytic enzymes, such as human neutrophil elastase (HNE), become highly expressed. Alanine-Alanine-Proline-Valine (AAPV) is an antimicrobial tetrapeptide capable of suppressing the HNE activity, restoring its expression to standard rates. Here, we proposed the...
Nanoparticle synthesis and their integration into polymer-based fibers for biom...
Domingues, Joana Margarida Dias; Miranda, Catarina S.; Homem, Natália Cândido; Felgueiras, Helena Prado; Antunes, Joana Isabel CostaThe potential of nanoparticles as effective drug delivery systems combined with the versatility of fibers has led to the development of new and improved strategies to help in the diagnosis and treatment of diseases. Nanoparticles have extraordinary characteristics that are helpful in several applications, including wound dressings, microbial balance approaches, tissue regeneration, and cancer treatment. Owing t...
Tunable spun fiber constructs in biomedicine: influence of processing parameter...
Miranda, Catarina S.; Silva, Ana Francisca G.; Pereira-Lima, Sílvia M. M. A.; Costa, Susana P. G.; Homem, Natália Cândido; Felgueiras, Helena PradoElectrospinning and wet-spinning have been recognized as two of the most efficient and promising techniques for producing polymeric fibrous constructs for a wide range of applications, including optics, electronics, food industry and biomedical applications. They have gained considerable attention in the past few decades because of their unique features and tunable architectures that can mimic desirable biologi...
Graphene oxide-based platforms for wound dressings and drug delivery systems: A...
Homem, Natália Cândido; Miranda, Catarina S.; Teixeira, Marta A.; Teixeira, Marta Sofia Aguiar Carvalho Oliveira; Domingues, Joana Margarida DiasIn the past few years, the outstanding properties of the best-known derivative of graphene, the graphene oxide (GO), have led to a wide increase of its spectra of application. GO-based composites have been reported as chemically and mechanically stable, presenting good biocompatibility and great antimicrobial potential. Also, GO's two-dimensional planar structure coupled with its large availability of oxygen-re...
Functionalization of crosslinked sodium alginate/gelatin wet-spun porous fibers...
Homem, Natália Cândido; Tavares, Tânia Daniela Eugénio; Miranda, Catarina S.; Antunes, Joana Isabel Costa; Amorim, M. T. Pessoa deNisin Z, an amphipathic peptide, with a significant antibacterial activity against Gram-positive bacteria and low toxicity in humans, has been studied for food preservation applications. Thus far, very little research has been done to explore its potential in biomedicine. Here, we report the modification of sodium alginate (SA) and gelatin (GN) blended microfibers, produced via the wet-spinning technique, with ...
Sodium alginate/gelatin wet-spun fibers as a delivery platform for Nisin Z cont...
Homem, Natália Cândido; Tavares, Tânia Daniela Eugénio; Miranda, Catarina S.; Barcellos, Lígia; Antunes, Joana Isabel Costa; Amorim, M. T. Pessoa de[Excerpt] The aim of this study was to produce SA/GN microfibers via wet-spinning technique, and subsequently functionalize these fibers with Nisin Z, in order to map Nisin Z’s controlled release kinetics and antimicrobial action against S. aureus
Fighting Pseudomonas aeruginosa-prevalent wound infections by means of natural-...
Miranda, Catarina S.; Antunes, Joana Isabel Costa; Homem, Natália Cândido; Felgueiras, Helena Prado[Excerpt] Pseudomonas aeruginosa is considered a public threat, with a great number of antibiotic resistant microorganisms. Essential oils (EOs) have demonstrated significant effects against several pathogens, however, they present a volatile nature, therefore, biodegradable polymeric delivery platforms are being engineered. Here, hydrogel-like films were produced from a combination of sodium alginate (SA) and ...