7 documents found, page 1 of 1
Clinical and Pathological Features of Double-Hit and Triple-Hit High-Grade B-Ce...
Almeida, Rui; Abrantes, Carlos; Gigliano, Davide; Oliveira, Rui Caetano; Teixeira, Paulo; Viegas, Marta; Rodrigues, Ângelo; Julião, Maria JoséBackground: High-grade B-cell lymphoma (HGBL) with rearrangements of MYC and BCL2 and/or BCL6, called double and triple-hit lymphomas (DTH-HGBL), are lymphoid malignancies with inferior outcomes when treated with standard chemotherapy. The identification of DTH-HGBL cases is challenging, considering their variable clinical, morphologic, and immunohistochemical features. Materials and Methods: Retrospective revi...
Gestão da dor na prática de enfermagem no serviço de urgência
Mota, Mauro; Cunha, Madalena; Reis Santos, Margarida; Duarte, João; Rocha, Ana Raquel; Rodrigues, Ângelo; Gonçalves, Carolina; Ribeiro, RúbenIntrodução: Em Portugal mais de 30% dos adultos apresenta dor crónica e a dor aguda assume-se como o principal motivo de admissão hospitalar, o que representa, anualmente, 5 mil milhões de euros, 2.7% do Produto Interno Bruto. Objetivos: Avaliar as práticas e os fatores intervenientes na gestão da dor pelos enfermeiros num Serviço de Urgência. Métodos: Estudo transversal analítico realizado em contexto de urgên...
Gestão da dor na prática de enfermagem no serviço de urgência
Mota, Mauro; Cunha, Madalena; Santos, Margarida Reis; Duarte, João; Rocha, Ana Raquel; Rodrigues, Ângelo; Gonçalves, Carolina; Ribeiro, RúbenIntrodução: Em Portugal mais de 30% dos adultos apresenta dor crónica e a dor aguda assume-se como o principal motivo de admissão hospitalar, o que representa, anualmente, 5 mil milhões de euros, 2.7% do Produto Interno Bruto. Objetivos: Avaliar as práticas e os fatores intervenientes na gestão da dor pelos enfermeiros num Serviço de Urgência. Métodos: Estudo transversal analítico realizado em contexto de urg...
High immunoexpression of Ki67, EZH2, and SMYD3 in diagnostic prostate biopsies ...
Lobo, João; Rodrigues, Ângelo; Antunes, Luís; Pinho dos Santos Graça, Maria Inês; Ramalho-Carvalho, João; Quintela Vieira, Ana FilipaOvertreatment is a major concern in patients with prostate cancer (PCa). Prognostic biomarkers discriminating indolent from aggressive disease in prostate biopsy are urgently needed. We aimed to evaluate the prognostic value of Ki67, EZH2, LSD1, and SMYD3 immunoexpression in diagnostic biopsies from a cohort of PCa patients with long term follow-up. A series of 189 consecutive prostate biopsies diagnosed with P...
Phenotypic impact of deregulated expression of class I histone deacetylases in ...
Neto, Susana; Quintela Vieira, Ana Filipa; Montezuma, Diana; Costa, Natália R.; Antunes, Luís; Baptista, Tiago; Oliveira, Ana IsabelDeregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 l...
Spinal Cord Compression by Testicular Germ Cell Tumor: Case Report
Estevinho, Fernanda; Sousa, Nuno; Rodrigues, Ângelo; Carneiro, Eduarda; Souto, João; Begonha, Rosa; Maurício, JoaquinaMalignant spinal cord compression occurs in 2.5% - 5% cancer patients. Early diagnosis and therapeutic intervention are critical for paincontrol and improvement of any neurological deficit. Treatment should be directed to the underlying disease together with appropriatesymptom management.The case of a man with tetraparesis of 24 hours duration is presented. He had surgery five days earlier because of a testicul...
Cover crops for the sustainability of rainfed olive orchards
Correia, Carlos; Brito, Cátia Vanessa Queijo; Ferreira, Helena; Rodrigues, Ângelo; Gonçalves, Berta; Santos, Dario; Bacelar, EuniceOlive tree (Olea europaea L.) is present in large areas of mainland Portugal, predominantly in less-favored regions. In spite of the fact that irrigated areas are currently increasing, most of the olive orchards are still cultivated under rainfed conditions. The success of olive farming under rainfed conditions is mainly due to the high capacity of olive tree to develop anatomical, physiological and biochemical...