5 documents found, page 1 of 1
Scientific and technological investigation of the protective effect of rutin on...
Fideles, Lázaro de Sousa; Miranda, João Antônio Leal de; Pimentel, Paulo Vitor de Souza; Ribeiro, Maria Elenir Nobre PinhoChemotherapy is one of the main oncological treatments, in which it has several side effects, including mucositis. Rutin belongs to the class of flavonoids and has clinically relevant functions, potentially beneficial in preventing diseases and antioxidant activity. Therefore, the objective of this study was to carry out scientific and technological monitoring of the pharmacological properties of rutin and its ...
Investigação científica e tecnológica do efeito protetor da rutina na mucosite ...
Fideles, Lázaro de Sousa; Miranda, João Antônio Leal de; Pimentel, Paulo Vitor de Souza; Ribeiro, Maria Elenir Nobre PinhoA quimioterapia é um dos principais tratamentos oncológicos, no qual acarreta diversos efeitos colaterais, dentre os quais têm-se a mucosite. A rutina pertence à classe dos flavonoides e apresenta clinicamente funções relevantes, potencialmente benéficas na prevenção de doenças e atividade antioxidante. Portanto, objetivou-se com esse estudo, realizar um monitoramento científico e tecnológico acerca das proprie...
Role of rutin in 5-Fluorouracil-induced intestinal mucositis : prevention of hi...
Fideles, Lázaro de Sousa; Miranda, João Antônio Leal de; Martins, Conceição da Silva; Barbosa, Maria Lucianny Lima; Pimenta, Helder BindáIntestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU). Rutin (RUT), a natural flavonoid extracted from Dimorphandra gardneriana, exhibits antioxidant, anti-inflammatory, cytoprotective, and gastroprotective properties. However, the effect of RUT on inflammatory process...
Protective Effect of cashew gum (Anacardium occidentale L.) on 5-Fluorouracil-i...
Miranda, João Antônio Leal de; Barreto, João Erivan Façanha; Martins, Dainesy Santos; Pimentel, Paulo Vitor de Souza; Costa, Deiziane Viana da SilvaIntestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Cashew gum (CG) has been reported as a potent anti-inflammatory agent. In the present study, we aimed to evaluate the e ect of CG extracted from the exudate of Anacardium occidentale L. on experimental intestinal mucositis induced by 5-FU. Swiss mice were randomly divided into...
Troxerrutina previne alterações morfológicas na mucosite intestinal induzida po...
Miranda, João Antônio Leal deIntestinal mucositis is a common complication associated to 5-Fluorouracil (5-FU) treatment, a chemotherapeutic agent widely used for cancer treatment. Troxerrutin (TRX) a semisynthetic flavonoid from the rutin, which is extracted from the Dimorphandra gardneriana, which has various pharmacological activities described as antioxidant and antiinflammatory. The aim of the present study was to evaluate the effect ...