13 documents found, page 1 of 2
Cost-effectiveness of Xpert®MTB/RIF in the diagnosis of tuberculosis: pragmatic...
Silva,Suely Conceição Alves da; Vater,Maria Claudia; Ramalho,Daniela Maria de Paula; Almeida,Isabela Neves de; Miranda,Silvana Spíndola deAbstract INTRODUCTION: The intensification of research and innovation with the creation of networks of rapid and effective molecular tests as strategies for the end of tuberculosis are essential to avoid late diagnosis and for the eradication of the disease. We aimed to evaluate the cost-effectiveness of Xpert®MTB/RIF (Xpert) in the diagnosis of drug-resistant tuberculosis in reference units, in scenarios with ...
Assessment of factors associated with potential drug-drug interactions in patie...
Resende,Natália Helena de; Miranda,Silvana Spíndola de; Ceccato,Maria das Graças Braga; Reis,Adriano Max Moreira; Haddad,João Paulo AmaralAbstract INTRODUCTION: The concomitant use of antituberculosis and antiretroviral drugs, as well as drugs to treat other diseases, can cause drug-drug interactions. This study aimed to describe potential drug-drug interactions (pDDI) in patients with TB and HIV/AIDS co-infection, as well as to analyze possible associated factors. METHODS: This study was performed in a reference hospital for infectious and conta...
Diagnosis of tuberculosis: a consensus statement from the Brazilian Thoracic As...
Silva,Denise Rossato; Rabahi,Marcelo Fouad; Sant’Anna,Clemax Couto; Silva-Junior,José Laerte Rodrigues da; Capone,Domenico; Bombarda,SidneyABSTRACT Early, accurate diagnosis of tuberculosis is one of the major pillars of the control of the disease. The purpose of this consensus statement is to provide health professionals with the most current, useful evidence for the diagnosis of tuberculosis in Brazil. To that end, the Tuberculosis Committee of the Brazilian Thoracic Association brought together 14 members of the Association with recognized expe...
The impact of the stratification by degree of clinical severity and abandonment...
Navarro,Pedro Daibert de; Haddad,João Paulo Amaral; Rabelo,Juliana Veiga Costa; Silva,Claudia Hermínia de Lima e; Almeida,Isabela Neves deABSTRACT Objective: Evaluate the impact of the instrument of the “Stratification by Degree of Clinical Severity and Abandonment Risk of Tuberculosis Treatment” (SRTB) on the tuberculosis outcome. Methods: This study was a pragmatic clinical trial involving patients with a confirmed diagnosis of tuberculosis treated at one of the 152 primary health care units in the city of Belo Horizonte, Brazil, between May of...
Cost analysis of smear microscopy and the Xpert assay for tuberculosis diagnosi...
Figueredo,Lida Jouca de Assis; Miranda,Silvana Spíndola de; Santos,Lucas Benício dos; Manso,Caroline Gontijo Gonçalves; Soares,Valéria MartinsAbstract INTRODUCTION: Rapid and accurate tuberculosis detection is critical for improving patient diagnosis and decreasing tuberculosis transmission. Molecular assays can significantly increase laboratory costs; therefore, the average time and economic impact should be evaluated before implementing a new technology. The aim of this study was to evaluate the cost and average turnaround time of smear microscopy ...
Spirometry results after treatment for pulmonary tuberculosis: comparison betwe...
Mancuzo,Eliane Viana; Martins Netto,Eduardo; Sulmonett,Nara; Viana,Vanessa de Souza; Croda,Júlio; Kritski,Afranio LineuABSTRACT Objective: To compare patients with and without previous lung disease, in terms of the spirometry results after they had been treated for pulmonary tuberculosis (PTB) and cured, as well as to analyze risk factors related to functional severity. Methods: This was a cross-sectional, multicenter study conducted at four referral centers in Brazil. Patients were divided into two groups: those with a history...
Drug therapy problems for patients with tuberculosis and HIV/AIDS at a referenc...
Resende,Natália Helena de; Miranda,Silvana Spíndola de; Ceccato,Maria das Graças Braga; Haddad,João Paulo Amaral; Reis,Adriano Max MoreiraABSTRACT Objective: To determine the frequency of drug therapy problem in the treatment of patients with tuberculosis and HIV/AIDS. Methods: Data were obtained through a cross-sectional study conducted between September 2015 and December 2016 at a reference hospital in infectious diseases in Belo Horizonte (MG), Brazil. Sociodemographic, clinical, behavioral and pharmacotherapeutic variables were evaluated thro...
Comparative study of RFLP-IS6110 and MIRU-VNTR from Mycobacterium tuberculosis ...
Augusto,Cláudio José; Carvalho,Wânia da Silva; Almeida,Isabela Neves de; Figueiredo,Lida Jouca de Assis; Dantas,Nayanne Gama TeixeiraAbstract DNA genotyping of Mycobacterium tuberculosis has been widely applied in the understanding of disease transmission in many countries. The purpose of this study was to genotype the strains of M. tuberculosis isolated in patients with new tuberculosis (TB) cases in Minas Gerais, as well as to compare the similarity, discriminatory power, and agreement of the clusters between the IS6110 Restriction Fragmen...
Spirometry reference values for Black adults in Brazil
Prata,Tarciane Aline; Mancuzo,Eliane; Pereira,Carlos Alberto de Castro; Miranda,Silvana Spíndola de; Sadigursky,Larissa Voss; Hirotsu,CamilaABSTRACT Objective: To derive reference equations for spirometry in healthy Black adult never smokers in Brazil, comparing them with those published in 2007 for White adults in the country. Methods: The examinations followed the standards recommended by the Brazilian Thoracic Association, and the spirometers employed met the technical requirements set forth in the guidelines of the American Thoracic Society/Eur...
Tuberculose intraocular
Campos,Wesley Ribeiro; Campos,Gisele Schelgshorn; Miranda,Silvana Spíndola deA Tuberculose (TB) é uma doença infecciosa causada pelo Mycobacterium tuberculosis (Mtb), que acomete principalmente os pulmões. Ela pode acometer qualquer parte do olho, porém o local mais acometido é a úvea. A incidência de envolvimento de TB ocular e em outros sítios é de 1% a 2%. Alguns autores descrevem várias alterações intraoculares, tendo apresentações clínicas das mais variadas, uveíte anterior, poster...