Objective: To assess whether the CAD/CAM technology is superior to the conventional technique for making Tissue Born total dentures. Methodology: This review followed the PRISMA recommendations. A systematic review was carried out by two calibrated reviewers in the Medline-PubMed, Scopus, Scielo, Lilacs, Web of Science and Cochrane Library databases, using the descriptors: “Complete denture”, “Complete dentures...