3 documents found, page 1 of 1
Generation of an obese diabetic mouse model upon conditional Atrx disruption
Gaspar, Tiago Bordeira; Jesus, Tito Teles; Azevedo, Maria Teresa; Macedo, Sofia; Soares, Mariana Alves; Martins, Rui Sousa; Leite, Rúben; Rodrigues, LiaATRX mutations occur in up to 17% of human pancreatic neuroendocrine tumours (PanNETs), and recent evidence points towards its inability to drive PanNET formation in mouse pancreas while predisposing individuals to inflammageing. Aiming to explore the additional non-tumourigenic consequences of Atrx deletion, we characterised an aged series of Atrx conditional disruption in β cells using the Pdx1 promoter. Homo...
Importance of students congresses for medical training: A pioneer experience at...
Saceanu Leser, Felipe; Nogueira Fiuza, Diogo; Miranda-Alves, LeandroO Congresso Acadêmico de Medicina da Universidade Federal do Rio de Janeiro (COAME-UFRJ) promove atividades teórico-práticas e apresentações de trabalhos científicos, dirigido especialmente a estudantes de medicina. Seu público está se expandindo para escolas médicas em todo o país. Apesar de sua relevância, a literatura carece de estudos que avaliem a influência dos eventos acadêmico-científicos na formação do...
Tributyltin chloride leads to adiposity and impairs metabolic functions in the ...
Bertuloso, Bruno D.; Podratz, Priscila L.; Merlo, Eduardo; de Araújo, Julia F.P.; Lima, Leandro C.F.; de Miguel, Emilio C.; de Souza, Leticia N.Made available in DSpace on 2022-04-29T08:44:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-05-09; Tributyltin chloride (TBT) is an environmental contaminant used in antifouling paints of boats. Endocrine disruptor effects of TBT are well established in animal models. However, the adverse effects on metabolism are less well understood. The toxicity of TBT in the white adipose tissue (WAT), liver and ...