16 documents found, page 1 of 2

Differential cellular effects of sunitinib and pazopanib targeted drugs for met...

MCT1 is a new prognostic biomarker and its therapeutic inhibition boosts respon...

<i>Background:</i> Glioblastomas (GBMs) present remarkable metabolism reprograming, in which many cells display the “Warburg effect”, with the production of high levels of lactate that are extruded to the tumour microenvironment by monocarboxylate transporters (MCTs). We described previously that MCT1 is up-regulated in human GBM samples, and MCT1 inhibition decreases glioma cell viability and aggressiveness. I...

Impacto no metabolismo de células de carcinoma de células renais ao tratamento ...

Sirtuins’ deregulation in bladder cancer: SIRT7 is implicated in tumor progress...

Sirtuins are emerging players in cancer biology and other age-related disorders, and their putative role in bladder cancer (BlCa) remains elusive. Further understanding of disease biology may allow for generation of more effective pathway-based biomarkers and targeted therapies. Herein, we aimed to illuminate the role of sirtuins’ family in BlCa and evaluate their potential as disease biomarkers and therapeutic...

Volatilomics reveals potential biomarkers for identification of renal cell carc...

The identification of noninvasive biomarkers able to detect renal cell carcinoma (RCC) at an early stage remains an unmet clinical need. The recognition that altered metabolism is a core hallmark of cancer boosted metabolomic studies focused in the search for cancer biomarkers. The present work aims to evaluate the performance of the volatile metabolites present in the extracellular medium to discriminate RCC c...

Volatile exometabolome profiling of human renal cell carcinoma cell lines for b...

Renal Cell Carcinoma (RCC) constitutes approximately 90-95% of all kidney neoplasms and is the second most lethal urological cancer. Current diagnostic techniques rely on imaging techniques and an invasive procedure (biopsy) is always required for histopathologic confirmation of malignancy. For these reasons, the identification of accurate biomarkers to develop faster, less invasive and more sophisticated diagn...

The Impact of [C16Pyr][Amp] on the Aggressiveness in Breast and Prostate Cancer...

Breast (BrCa) and prostate (PCa) cancers are the most common malignancies in women and men, respectively. The available therapeutic options for these tumors are still not curative and have severe side e↵ects. Therefore, there is an urgent need for more e↵ective antineoplastic agents. Herein, BrCa, PCa, and benign cell lines were treated with two ionic liquids and two quinoxalines and functional experiments were...

Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy an...

Glioblastoma (GBM) is the most frequent and aggressive type of brain tumor. There are limited therapeutic options for GBM so that new and effective agents are urgently needed. Euphol is a tetracyclic triterpene alcohol, and it is the main constituent of the sap of the medicinal plant Euphorbia tirucalli. We previously identified anti-cancer activity in euphol based on the cytotoxicity screening of 73 human canc...

Molecular impact of [C16Pyr][Amp] treatment on breast and prostate cancer cell ...

Prostate Cancer (PCa) and Breast Cancer (BCa) are the leading causes of cancer morbidity and mortality, worldwide, when diagnosed in advanced stages of the disease. Currently available therapies have limited curative effect, leading to the progression to highly aggressive hormone-resistant phenotypes. Thus, the development of new anti-tumor agents becomes imperative. Ionic liquids are organic salts with anti-ne...

Alginate hydrogel improves anti-angiogenic bevacizumab activity in cancer therapy

Made available in DSpace on 2018-12-11T16:48:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-10-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); European Regional Development Fund; Fundação para a Ciência e a Tecnologia; Anti-vascular endothelial growth factor (anti-VEGF) therapy applied to solid tumors is a ...