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A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic ...
Fonseca-Gomes, João; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H.; Alemãn-Serrano, NunoPublisher Copyright: Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.; In Alzheimer's disease (AD), amyloid β (Aβ)-triggered cleavage of TrkB-FL impairs brain-derived neurotrophic factor (BDNF) signaling, thereby compromising neuronal survival, differentiation, and synaptic transmission and plasticity. Using cerebrospinal fluid and postmortem human brain samples, we show that TrkB...
Unexpected short- and long-term effects of chronic adolescent HU-210 exposure o...
Farinha-Ferreira, Miguel; Rei, Nádia; Fonseca-Gomes, João; Miranda-Lourenço, Catarina; Serrão, Paula; Vaz, Sandra H.; Gomes, Joana I.; Martins, ValériaFunding Information: Work was supported by project funding from Fundação para a Ciência e para a Tecnologia (FCT) ( PTDC/MED-FAR/30933/2017 and PTDC/MED-FAR/4834/2021 ) and by H2020-WIDESPREAD-05-2017-Twinning (EpiEpinet) under grant agreement No. 952455 . MF-F ( SFRH/BD/147505/2019 ), NR ( PD/BD/113463/2015 ), JF-G ( PD/BD/114441/2016 ) and CM-L ( SFRH/BD/118238/2016 ) are supported by PhD fellowships from FCT...