3 documents found, page 1 of 1
A non-genetic model of vascular shunts informs on the cellular mechanisms of fo...
Ouarné, Marie; Pena, Andreia; Ramalho, Daniela; Conchinha, Nadine V.; Costa, Tiago; Enjalbert, Romain; Figueiredo, Ana M.; Saraiva, Marta PimentelAIMS: Arteriovenous malformations (AVMs), a disorder characterized by direct shunts between arteries and veins, are associated with genetic mutations. However, the mechanisms leading to AV shunt formation and how shunts can be reverted are poorly understood. METHODS AND RESULTS: Here, we report that oxygen-induced retinopathy (OIR) protocol leads to the consistent and stereotypical formation of AV shunts in non...
A non-genetic model of vascular shunts informs on the cellular mechanisms of fo...
Ouarné, Marie; Pena, Andreia; Ramalho, Daniela; Conchinha, Nadine V.; Costa, Tiago; Figueiredo, Ana; Saraiva, Marta Pimentel; Carvalho, YuliaArteriovenous malformations (AVMs), a disorder characterized by direct shunts between arteries and veins, are associated with genetic mutations. However, the mechanisms leading to the transformation of a capillary into a shunt remain unclear and how shunts can be reverted into capillaries is poorly understood. Here, we report that oxygen-induced retinopathy (OIR) protocol leads to the consistent and stereotypic...
Competition for endothelial cell polarity drives vascular morphogenesis in the ...
Barbacena, Pedro; Dominguez-Cejudo, Maria; Fonseca, Catarina G.; Gómez-González, Manuel; Faure, Laura M.; Zarkada, Georgia; Pena, AndreiaBlood-vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that the transition between two fundamental vascular morphogenetic programs—sprouting angiogenesis and vascular remodeling—is established by a shift of collective front-to-rear polarity of endothelial cells ...