3 documents found, page 1 of 1
Antimicrobial activities of highly bioavailable organic salts and ionic liquids...
Santos, Miguel M.; Alves, Celso; Silva, Joana; Florindo, Catarina; Costa, Alexandra; Petrovski, Željko; Marrucho, Isabel M.; Pedrosa, RuiUIDB/50006/2020 PTDC/QUI-QOR/32406/2017 PEst-C/LA0006/2013 RECI/BBBBQB/0230/2012; As the development of novel antibiotics has been at a halt for several decades, chemically enhancing existing drugs is a very promising approach to drug development. Herein, we report the preparation of twelve organic salts and ionic liquids (OSILs) from ciprofloxacin and norfloxacin as anions with enhanced antimicrobial activity....
Highly water soluble room temperature superionic liquids of APIs
Carrera, Gonçalo V. S. M.; Santos, Miguel M.; Costa, Alexandra; Rebelo, Luis Paulo N.; Marrucho, Isabel M.; Nunes da Ponte, M.; Branco, Luis C.Fundacao para a Ciencia e a Tecnologia through project (PEst-C/LA0006/2013). The authors also thank Prof. Madalena Dionisio and Dr Natalia Correia for their support with the DSC analyses.; Herein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molte...
Novel biocompatible ionic liquids based on gluconate anion
Costa, Alexandra; Forte, Andreia; Zalewska, Karolina; Tiago, Gonçalo; Petrovski, Zeljko; Branco, Luís C.A sustainable organic synthetic methodology for the preparation of novel biocompatible ionic liquids (ILs) based on gluconate anion has been developed. Four functionalized methylimidazolium cations were efficiently combined with gluconic acid by acid-base neutralization reactions. All salts were obtained as RTILs in high yields (92–98%) and in high purity levels. Proton Nuclear Magnetic Resonance (1H NMR) studi...