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Longitudinal assessment of migraine burden in resistant and refractory migraine...

Pensato, Umberto; Ornello, Raffaele; Rosignoli, Chiara; Caponnetto, Valeria; Onofri, Agnese; Braschinsky, Mark; Sved, Olga; Gil-Gouveia, Raquel

Background: Some individuals with migraine fail to respond adequately to preventive treatments, bearing most of migraine burden. The European Headache Federation (EHF) classifies these individuals into resistant migraine (ResM) or refractory migraine (RefM) according to treatment failures, debilitating headache days, and disease duration. We investigated the evolution of these categories over six months in pati...


Hallmarks of primary headache: part 3 - cluster headache

Coppola, Gianluca; Arruda, Marco Antônio; Ashina, Messoud; Barloese, Mads; Belin, Andrea Carmine; Bottiroli, Sara; Chowdhury, Debashish

Background: Cluster headache (CH) is a rare primary headache disorder characterized by recurrent episodes of strictly unilateral excruciating pain accompanied by trigemino-autonomic signs, which significantly impacts the quality of life, social interactions, and occupational functioning of those who are affected. To promote a better understanding of this disabling condition and to foster research on the topic, ...


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