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Poly-N-acetylglucosamine production by Staphylococcus epidermidis cells increas...

Ferreirinha, P; Pérez-Cabezas, B; Correia, A; Miyazawa, B; França, A; Carvalhais, V; Faustino, A; Cordeiro-da-Silva, A; Teixeira, L; Pier, G; Cerca, N

Poly-N-acetylglucosamine (PNAG) is a major component of the Staphylococcus epidermidis biofilm extracellular matrix. However, it is not yet clear how this polysaccharide impacts the host immune response and infection-associated pathology. Faster neutrophil recruitment and bacterial clearance were observed in mice challenged intraperitoneally with S. epidermidis biofilm cells of the PNAG-producing 9142 strain th...


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