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Efeitos da Terapia com Anti-TNF alfa na Pressão Arterial em Pacientes com Hiper...
Faria,Ana Paula de; Ritter,Alessandra M. V.; Santa-Catharina,Arthur; Souza,Débora P.; Naseri,Estephania P.; Bertolo,Manoel B.; Pioli,Mariana RodriguesResumo Fundamento: A citocina fator de necrose tumoral alfa (TNF-α) é elevada na hipertensão resistente (HAR), mas os efeitos dos inibidores de TNF-α nessa população ainda são desconhecidos. Objetivos: O objetivo deste estudo foi avaliar se uma única dose de infliximabe controlada por placebo reduz a pressão arterial (PA) de forma aguda em pacientes com HAR. Métodos: Realizamos um estudo cruzado, randomizado, d...
O Escore Gensini e a Carga Trombótica Adicionam Valor Preditivo ao Escore SYNTA...
Matos,Luís Carlos V; Carvalho,Luiz Sergio; Modolo,Rodrigo; Santos,Simone; Silva,José Carlos Quinaglia e; Almeida,Osório Luis Rangel deResumo Fundamento O fenômeno de no-reflow após a intervenção coronária percutânea está associado a um pior prognóstico em pacientes com infarto do miocárdio com supradesnivelamento do segmento ST (IAMCSST). O escore SYNTAX é um bom preditor de no-reflow. Objetivo Nosso objetivo foi avaliar se a carga aterosclerótica (escore Gensini) e a carga trombótica na artéria coronária culpada melhorariam a capacidade do e...
A Proposed Inflammatory Score of Circulating Cytokines/Adipokines Associated wi...
Faria,Ana Paula de; Ritter,Alessandra Mileni Versuti; Gasparetti,Carolina Souza; Corrêa,Nathália Batista; Brunelli,Veridiana; Almeida,AurélioAbstract Background: There is evidence that subclinical systemic inflammation is present in resistant hypertension (RHTN). Objective: The aim of the study was to develop an integrated measure of circulating cytokines/adipokines involved in the pathophysiology of RHTN. Methods: RHTN (n = 112) and mild to moderate hypertensive (HTN) subjects (n=112) were studied in a cross-sectional design. Plasma cytokines/adipo...
Metabolic Syndrome-Related Features in Controlled and Resistant Hypertensive Su...
Catharina,Arthur Santa; Modolo,Rodrigo; Ritter,Alessandra Mileni Versuti; Sabbatini,Andréa Rodrigues; Lopes,Heno Ferreira; Moreno Junior,HeitorAbstract Background: Metabolic syndrome (MetS) is widespread among hypertensive patients. Clinical features and potential biomarkers of MetS in the presence of hypertension and resistant hypertension (RHTN) represent a great area of interest for investigation. Objective: The purpose of this study was to evaluate the prevalence of MetS and the clinical features associated with it in resistant and mild to moderat...
The Role of Quantitative Aortographic Assessment of Aortic Regurgitation by Vid...
Miyazaki,Yosuke; Modolo,Rodrigo; Abdelghani,Mohammad; Tateishi,Hiroki; Cavalcante,Rafael; Collet,Carlos; Asano,Taku; Katagiri,Yuki; Tenekecioglu,ErhanAbstract Background: Balloon post-dilatation (BPD) is often needed for optimizing transcatheter heart valve (THV) implantation, since paravalvular leak (PVL) after transcatheter aortic valve implantation is associated with poor outcome and mortality. Quantitative assessment of PVL severity before and after BPD is mandatory to properly assess PVL, thus improving implantation results and outcomes. Objective: To i...
MCP-1 Levels are Associated with Cardiac Remodeling but not with Resistant Hype...
Ritter,Alessandra Mileni Versuti; Faria,Ana Paula Cabral de; Sabbatini,Andrea; Corrêa,Nathalia Batista; Brunelli,Veridiana; Modolo,RodrigoAbstract Background: Hypertension is a chronic, low-grade inflammation process associated with the release of cytokines and development of target organ damage. Deregulated monocyte chemoattractant protein-1 (MCP-1) levels have been associated with high blood pressure and cardiovascular complications; however, the mechanisms involved are complex and not fully understood. Objective: This study aimed to compare th...
Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in R...
Faria,Ana Paula Cabral de; Modolo,Rodrigo; Moreno,Beatriz Vaz Domingues; Moreno,HeitorResistant hypertension (RHTN) is a multifactorial disease characterized by blood pressure (BP) levels above goal (140/90 mmHg) in spite of the concurrent use of three or more antihypertensive drugs of different classes. Moreover, it is well known that RHTN subjects have high prevalence of left ventricular diastolic dysfunction (LVDD), which leads to increased risk of heart failure progression. This review gathe...