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Estudo farmacológico pré-clínico de análogos de LASSBio-1586 candidatos a protó...
Carneiro, Teiliane RodriguesIn Brazil, the estimate for the biennium 2016-2017 indicates the occurrence of 600.000 new cases of cancer. Combretastatin A4 (CA-4), found in the bark of Combretum caffrum, is the compound with simpler chemical structure known to exert potent cytotoxic activity, through reversible interaction with the colchicine site of β-tubulin. In recent years, it has been studied and pointed with great potential anticancer...
Natural products as new antimitotic compounds for anticancer drug development
Paier, Carlos Roberto Koscky; Maranhão, Sarah Sant’Anna; Carneiro, Teiliane Rodrigues; Lima, Lídia Moreira; Rocha, Danilo DamascenoCell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied because they induce cell cycle arrest and tumor cell death. These antitumor compounds are referred to as antimitotics....
Increased detection of schistosomiasis with Kato-Katz and SWAPIgG- ELISA in a N...
Pinheiro, Marta Cristhiany Cunha; Oliveira, Sara Menezes de; Hanemann, Ana Lúcia de Paula; Queiroz, José Ajax NogueiraIntroduction: The laboratory diagnosis of schistosomiasis is based mainly on the detection of parasite eggs in stool samples through the Kato-Katz (KK) technique, reading one slide by test. However, a widely known limitation of parasitological methods is reduced sensitivity, particularly in low endemic areas. Methods: To increase sensitivity, we conducted further slide readings from the same stool sample using ...
Avaliação da reação em cadeia da polimerase (PCR) em amostras de fezes para dia...
Carneiro, Teiliane RodriguesSchistosomiasis is still a public health problem in Brazil. The infection is widespread in southeast and northeast. The laboratorial diagnosis of schistosome infection has been based on direct coproscopic examination and by indirect methods for detection of antigen, antibodies and specific DNA fragments that are associated with Schistosoma mansoni infection. The aim of the present study was to evaluate polymera...