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Evolutionary Constraints in the b-Globin Cluster: The Signature of Purifying Se...

Moleirinho, A; Seixas, A; Lopes, AM; Bento, C; Prata, MJ; Amorim, A

Human hemoglobins, the oxygen carriers in the blood, are composed by two α-like and two β-like globin monomers. The β-globin gene cluster located at 11p15.5 comprises one pseudogene and five genes whose expression undergoes two critical switches: the embryonic-to-fetal and fetal-to-adult transition. HBD encodes the δ-globin chain of the minor adult hemoglobin (HbA2), which is assumed to be physiologically irrel...

Date: 2013   |   Origin: Repositório do Centro Hospitalar e Universitário de Coimbra
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