5 documents found, page 1 of 1
ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development...
Marcolino, Milena S.; Pires, Magda C.; Ramos, Lucas Emanuel F.; Silva, Rafael T.; Oliveira, Luana M.; Carvalho, Rafael L.R.; Mourato, Rodolfo Lucas S.Made available in DSpace on 2022-04-29T08:31:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Objectives: The majority of available scores to assess mortality risk of coronavirus disease 2019 (COVID-19) patients in the emergency department have high risk of bias. Therefore, this cohort aimed to develop and validate a score at ...
The effect of benznidazole dose among the efficacy outcome in the murine animal...
Molina, Israel; Melo, Luísa Helena Perin de; Aviles, Augusto Sao; Vieira, Paula Melo de Abreu; Fonseca, Kátia da Silva; Cunha, Lucas MacielDespite more than 100 years since it was firstly described Chagas disease, only two drugs are available to treat Chagas disease: Nifurtimox launched by Bayer in 1965 and benznidazole launched by Roche in 1971. Drug discovery initiatives have been looking for new compounds as an alternative to these old drugs. Although new platforms have been used with the latest technologies, a critical step on that process sti...
Course of serological tests in treated subjects with chronic Trypanosoma cruzi ...
Sguassero, Yanina; Roberts, Karen N.; Harvey, Guillermina B.; Comandé, Daniel; Cuesta, Cristina B.; Aguiar, Camila; Castro, Ana M. de; Danesi, EmmaríaObjective To determine the course of serological tests in subjects with chronic Trypanosoma cruzi infection treated with anti-trypanosomal drugs. Methods A systematic review and meta-analysis was conducted using individual participant data. Survival analysis and the Cox proportional hazards regression model with random effects to adjust for covariates were applied. The protocol was registered in the PROSPERO da...
Experimental and clinical treatment of Chagas disease : a review.
Sales Júnior, Policarpo Ademar; Molina, Israel; Murta, Silvane Maria Fonseca; Sánchez Montalvá, Adrián; Salvador, Fernando; Oliveira, Rodrigo Corrêa deChagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a broad range of triatomines and mammalian species, including man. It afflicts 8 million people in Latin America, and its incidence is increasing in nonendemic countries owing to rising international immigration and nonvectorial transmission routes such as blood donation. Since the 1960s, the only drugs available for the clin...
Pharmacokinetic and tissue distribution of benznidazole after oral administrati...
Melo, Luísa Helena Perin de; Silva, Rodrigo Moreira da; Fonseca, Kátia da Silva; Cardoso, Jamille Mirelle de OliveiraSpecific chemotherapy using benznidazole (BNZ) for Chagas disease during the chronic stage is controversial due to its limited efficacy and toxic effects. Although BNZ has been used to treat Chagas disease since the 1970s, few studies about the biodistribution of this drug exist. In this study, BNZ tissue biodistribution in a murine model and its pharmacokinetic profile in plasma were monitored. A bioanalytical...