3 documents found, page 1 of 1
Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
Sharifi-Rad, J; Quispe, C; Mukazhanova, Z; Knut, E; Turgumbayeva, A; Kipchakbayeva, A; Seitimova, G; Mahomoodally, MF; Lobine, D; Koay, A; Wang, JResveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effec...
Impact of natural compounds on neurodegenerative disorders: From preclinical to...
Sharifi-Rad, M; Lankatillake, C; Dias, DA; Docea, AO; Mahomoodally, MF; Lobine, D; Chazot, PL; Kurt, B; Tumer, TB; Moreira, AC; Sharopov, FAmong the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their...
Insights on the use of a-lipoic acid for therapeutic purposes
Salehi, B; Yilmaz, YB; Antika, G; Boyunegmez, TT; Fawzi, MM; Lobine, D; Akram, M; Riaz, M; Capanoglu, E; Sharopov, F; Martins, N; Cho, WCa-lipoic acid (ALA, thioctic acid) is an organosulfur component produced from plants, animals, and humans. It has various properties, among them great antioxidant potential and is widely used as a racemic drug for diabetic polyneuropathy-associated pain and paresthesia. Naturally, ALA is located in mitochondria, where it is used as a cofactor for pyruvate dehydrogenase (PDH) and a-ketoglutarate dehydrogenase co...