29 documents found, page 1 of 3
Evaluation of diagnosis and treatment practices of Brazilian neurologists among...
Marin,Cássia Elisa; Callegaro,Dagoberto; Lana-Peixoto,Marco Aurélio; Fernández,Oscar; Gomes Neto,Antonio Pereira; Vasconcelos,Claudia Cristina FerreiraABSTRACT Background: Recent changes to the diagnostic criteria for multiple sclerosis (MS) and new medications have had a major impact on the way in which specialists manage the disease. Objective: To investigate factors considered by Brazilian neurologists in managing MS, and to identify how these contribute to diagnosis and treatment. Methods: Potential participants were selected by a steering committee (MS e...
Prevalence of multiple sclerosis in key cities of Brazil: a study in Passo Fund...
Passos,Giordani Rodrigues dos; Becker,Jefferson; Varela,Daniel Lima; Fröhlich,Alan Christmann; Rech,Bruna Constantino; Mattos,Ana Carolina Squeff deABSTRACT Background: To improve the comparability of multiple sclerosis (MS) prevalence across Brazilian regions, the Brazilian Committee for Treatment and Research in MS has implemented a standardized approach to assess the prevalence of the disease in five key cities, which were deemed representative of their regions in terms of socio-geographical features and where in-person revision of each case was feasibl...
Recommendations by the Scientific Department of Neuroimmunology of the Brazilia...
Becker,Jefferson; Ferreira,Lis Campos; Damasceno,Alfredo; Bichuetti,Denis Bernardi; Christo,Paulo Pereira; Callegaro,DagobertoABSTRACT The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) provide recommendations in this document for vaccination of the population with demyelinating diseases of the central nervous system (CNS) against infections in general and against the severe acut...
Normative values of the Brief Repeatable Battery of Neuropsychological Tests in...
Damasceno,Alfredo; Amaral,Juliana Machado Santiago dos Santos; Barreira,Amilton Antunes; Becker,Jefferson; Callegaro,Dagoberto; Campanholo,Kenia RepisoABSTRACT Objective Cognitive dysfunction is common in multiple sclerosis. The Brief Repeatable Battery of Neuropsychological Tests (BRB–N) was developed to assess cognitive functions most–frequently impaired in multiple sclerosis. However, normative values are lacking in Brazil. Therefore, we aimed to provide continuous and discrete normative values for the BRB–N in a Brazilian population sample. Methods We rec...
Longitudinal analysis of verbal episodic memory in patients with relapsing-remi...
Boa,Izadora Nogueira Fonte; Rimkus,Carolina de Medeiros; Campanholo,Kenia Repiso; Pereira,Samira Luisa Apóstolos; Junqueira,Thiago de FariaABSTRACT Objective: A 4.5-year follow-up study was conducted to characterize baseline verbal episodic memory (VEM) and its behavior and to assess the effects of relapsing-remitting multiple sclerosis (RRMS) on this domain. Methods: Twenty-nine patients with RRMS underwent two neuropsychological assessments performed an average of 4.5 years apart. Twenty-six control participants underwent a single neuropsycholog...
Brazilian Consensus for the Treatment of Multiple Sclerosis: Brazilian Academy ...
Marques,Vanessa Daccach; Passos,Giordani Rodrigues dos; Mendes,Maria Fernanda; Callegaro,Dagoberto; Lana-Peixoto,Marco AurélioABSTRACT The expanding therapeutic arsenal in multiple sclerosis (MS) has allowed for more effective and personalized treatment, but the choice and management of disease-modifying therapies (DMTs) is becoming increasingly complex. In this context, experts from the Brazilian Committee on Treatment and Research in Multiple Sclerosis and the Neuroimmunology Scientific Department of the Brazilian Academy of Neurolo...
A disturbed processing of graviceptive pathways may be involved in the pathophy...
Fonseca,Bruna Antinori Vignola da; Pereira,Cristiana Borges; Jorge,Frederico; Simm,Renata; Apostolos-Pereira,Samira; Callegaro,DagobertoABSTRACT The purpose of this study was to determine the relationship between perception of verticality and balance disorders in multiple sclerosis patients. We evaluated patients and healthy controls. Patients were divided into two groups according to their risk of fall, with or without risk of fall, measured by a Dynamic Gait Index scale. Graviceptive perception was assessed using the subjective visual vertica...
Natalizumab treatment in multiple sclerosis: the experience from two Brazilian ...
Oliveira,Enedina Maria Lobato de; Simm,Renata Faria; Dasic,Gorana; Morais,Marília Mamprim de; Perreira,Samira Luiza dos Apostolos; Callegaro,DagobertoObjective Analyze the demographics, clinical characteristics, efficacy and safety of natalizumab treatment in Brazilian patients with multiple sclerosis (MS) followed up for at least 12 months, in two tertiary MS care centers in São Paulo.Method We evaluated the effect of natalizumab treatment on annualized relapse rate and disability progression in 75 patients with MS treated with natalizumab for at least 12 m...
Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definiti...
Sato,Douglas Kazutoshi; Callegaro,Dagoberto; Lana-Peixoto,Marco Aurélio; Nakashima,Ichiro; Fujihara,KazuoNeuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cell-based assays....
Natalizumab treatment for multiple sclerosis: updates and considerations for sa...
Nali,Luiz Henrique da Silva; Moraes,Lenira; Fink,Maria Cristina Domingues; Callegaro,Dagoberto; Romano,Camila Malta; Oliveira,Augusto Cesar Penalva deNatalizumab is currently one of the best options for treatment of patients with Multiple Sclerosis who have failed traditional prior therapies. However, prolonged use, prior immunosuppressive therapy and anti-JCV antibody status have been associated with increased risk of developing progressive multifocal leukoencephalopathy (PML). The evaluation of these conditions has been used to estimate risks of PML in the...