3 documents found, page 1 of 1
Mitochondria as biological targets for stem cell and organismal senescence
Branco, Ana; Moniz, Inês; Santos, João RamalhoOrganismal aging is impacted by the deterioration of tissue turnover mechanisms due, in part, to the decline in stem cell function. This decline can be related to mitochondrial dysfunction and underlying energetic defects that, in concert, help drive biological aging. Thus, mitochondria have been described as a potential interventional target to hinder the loss of stem cell robustness, and subsequently, decreas...
Improving the performance of a SME in the cutlery sector using lean thinking an...
Dinis-Carvalho, José; Sousa, Rui M.; Moniz, Inês; Macedo, Helena Isabel Lopes; Lima, Rui M.The main purpose of this paper is to show that if three specific contextual factors are present in a company, it is possible to achieve great performance improvements with a lean and industry 4.0 implementation. In terms of research methods, a case study was carried out of a project to implement digitalization and Lean practices in a cutlery company, which in fact encompassed a project of master’s degree in eng...
Differential Oxygen Exposure Modulates Mesenchymal Stem Cell Metabolism and Pro...
Moniz, Inês; Ramalho-Santos, João; Branco, Ana F.Mesenchymal stem cells reside under precise hypoxic conditions that are paramount in determining cell fate and behavior (metabolism, proliferation, differentiation, etc.). In this work, we show that different oxygen tensions promote a distinct proliferative response and affect the biosynthetic demand and global metabolic profile of umbilical cord-mesenchymal stem cells (UC-MSCs). Using both gas-based strategies...