12 documents found, page 1 of 2
Home Mechanical Ventilation in Adults: Clinical Practice Recommendations from t...
Ribeiro, Carla; Gomes, Rita; Carreiro, Alexandra; Vieira, Ana Luísa; Seabra, Bárbara; Conde, Bebiana; Nogueira, Carla; Jácome, Cristina; Lages, JoanaThe use of home mechanical ventilation (HMV) has been increasing worldwide, driven by widening of clinical applications and improved patient survival rates. In Portugal, recent data indicate an even faster growth, although national HMV recommendations have remained unchanged for 25 years. We aimed to provide an update in clinical practice guidelines for HMV in adults, applicable to the Portuguese context, groun...
Home mechanical ventilation in adults
Ribeiro, Carla; Gomes, Rita; Carreiro, Alexandra; Vieira, Ana Luísa; Seabra, Bárbara; Conde, Bebiana; Nogueira, Carla; Jácome, Cristina; Lages, JoanaBackground: The use of home mechanical ventilation (HMV) has been increasing worldwide, driven by widening of clinical applications and improved patient survival rates. In Portugal, recent data indicate an even faster growth, although national HMV recommendations have remained unchanged for 25 years. Research question: We aimed to provide an update in clinical practice guidelines for HMV in adults, applicable t...
Biocompatible thermosensitive nanostructures and hydrogels of an amino acid-der...
Oliveira, Isabel S.; Silva, João P.N.; Araújo, Maria João; Gomes, Andreia C; Marques, Eduardo F.Aqueous surfactant/polymer mixtures form colloidal structures of great fundamental interest and practical relevance, such as nanostructured hydrogels for biomedical and pharmaceutical uses. In this work, we investigated the phase behavior, structure and cytotoxicity of mixtures of a double-tailed lysine-based surfactant, 16Lys12, and two hydroxyethyl cellulose (HEC) derivatives, JR400 and LM200. The surfactant,...
Hereditary Hemorrhagic Telangiectasia: Proposal of a Multidisciplinary Referral...
Costa, Isabel; Gonçalves, Inês; Mendes, Sofia; Araújo, Maria João; Caldas, Regina; Rodrigues, Berta; Dias, LuísN/a.; N/a.
Structure of Hierridin C, Synthesis of Hierridins B and C, and Evidence for Pre...
Costa, Margarida; Sampaio-Dias, Ivo E.; Castelo-Branco, Raquel; Scharfenstein, Hugo; Rezende de Castro, Roberta; Silva, Artur; Schneider, Maria Paula C.Small, single-celled planktonic cyanobacteria are ubiquitous in the world's oceans yet tend not to be perceived as secondary metabolite-rich organisms. Here we report the isolation and structure elucidation of hierridin C, a minor metabolite obtained from the cultured picocyanobacterium Cyanobium sp. LEGE 06113. We describe a simple, straightforward synthetic route to the scarcely produced hierridins that relie...
Development of a synthetic route towards N4 ,N9 -disubstituted 4,9-diaminoacrid...
Fonte, Mélanie; Fagundes, Natália; Gomes, Ana; Ferraz, Ricardo; Prudêncio, Cristina; Araújo, Maria João; Gomes, Paula; Teixeira, CátiaMalaria is one of the deadliest infectious diseases in the world and was responsible for 435 000 deaths in 2017, namely by Plasmodium falciparum species.1 Antimalarial drugs are the unique weapon to fight this disease once there is no vaccine yet. Generally antimalarial chemotherapy targets mainly the pathogenic blood stage in humans. However, there is an urgent need of new, economic and safe drugs in order to:...
Structure of Hierridin C, Synthesis of Hierridins B and C, and Evidence for Pre...
Costa, Margarida; Sampaio-Dias, Ivo E.; Castelo-Branco, Raquel; Scharfenstein, Hugo; Rezende de Castro, Roberta; Silva, Artur; Schneider, Maria Paula C.Small, single-celled planktonic cyanobacteria are ubiquitous in the world's oceans yet tend not to be perceived as secondary metabolite-rich organisms. Here we report the isolation and structure elucidation of hierridin C, a minor metabolite obtained from the cultured picocyanobacterium Cyanobium sp. LEGE 06113. We describe a simple, straightforward synthetic route to the scarcely produced hierridins that relie...
Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridin...
Fonte, Mélanie; Fagundes, Natália; Gomes, Ana; Ferraz, Ricardo; Prudêncio, Cristina; Araújo, Maria João; Gomes, Paula; Teixeira, CátiaA multi-step synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines that, to the best of our knowledge, has no precedence in the literature, has been developed. The target structures are likely to reveal interesting biological activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalari...
11(th) National Meeting of Organic Chemistry and 4(th) Meeting of Therapeutic C...
Sousa, Maria Emília; Araújo, Maria João; do Vale, Maria Luísa; Andrade, Paula B; Branco, Paula Sério; Gomes, Paula; Moreira, RuiFor the first time under the auspices of Sociedade Portuguesa de Química, the competences of two important fields of Chemistry are brought together into a single event, the 11st National Organic Chemistry Meeting and the the 4th National Medicinal Chemistry Meeting, to highlight complementarities and to promote new synergies. Abstracts of plenary lectures, oral communications, and posters presented during the m...
When three generations fall ill simultaneously
Araújo, Maria João; Viegas, Ana; Ribeiro, AnaIntroduction: Disease may be a cause or consequence of loss of family homeostasis. The general practitioner plays a special role in identifying family risk factors and recognizing resources and coping strategies during illness. This may be difficult when several family members are ill simultaneously. Case description: A. is a 37 year-old, Caucasian female, belonging to a nuclear family, in phase IV of the Duval...