4 documents found, page 1 of 1
Dietary antioxidants in coffee leaves: impact of botanical origin and maturity ...
Monteiro, Ângelo; Colomban, Silvia; Azinheira, Helena; Guerra-Guimarães, Leonor; Silva, Maria do Céu; Navarini, Luciano; Resmini, MarinaNatural polyphenols are important dietary antioxidants that significantly benefit human health. Coffee and tea have been shown to largely contribute to the dietary intake of these antioxidants in several populations. More recently, the use of coffee leaves to produce tea has become a potential commercial target, therefore prompting studies on the quantification of polyphenols in coffee leaves. In this study a v...
Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindol...
Soares, Joana; Raimundo, Liliana; Pereira, Nuno A. L.; Monteiro, Ângelo; Gomes, Sara; Bessa, Cláudia; Pereira, Clara; Queiroz, Glória; Bisio, AlessandraRestoration of the p53 pathway, namely by reactivation of mutant (mut) p53, represents a valuable anticancer strategy. Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of wild-type (wt) and mut p53, using a yeast-based screening strategy. SLMP53-1 has a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressi...
Enantiopure Indolizinoindolones with in vitro activity against blood- and liver...
Pereira, Nuno A. L.; Monteiro, Ângelo; Machado, Marta; Gut, Jiri; Molins, Elies; Perry, Maria Jesus; Dourado, Jorge; Moreira, Rui; Rosenthal, Philip J.Malaria continues to be a major cause of morbidity and mortality to this day, and resistance to drugs like chloroquine has led to an urgent need to discover novel chemical entities aimed at new targets. Here, we report the discovery of a novel class of potential antimalarial compounds containing an indolizinoindolone scaffold. These novel enantiopure indolizinoindolones were synthesized, in good-to-excellent yi...
Limiting internal supply voltage spikes in DC-DC converters
Rocha, José; Santos, Marcelino; Monteiro, Ângelo; Neves, Alexandre; Braga, PedroImplementing monolithic DC-DC converters for low power portable applications with a standard low voltage CMOS technology leads to lower production costs and higher reliability. Moreover, it allows miniaturization by the integration of two units in the same die: the power management unit that regulates the supply voltage for the second unit, a dedicated signal processor, that performs the functions required. Thi...