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Health and safety concerns related to CNT and graphene products, and related co...
Sousa, Susana P.B.; Peixoto, Tânia; Santos, Raquel M.; Lopes, Ascensão; Paiva, M. C.; Marques, António T.The use of Carbon Nanotubes (CNT) and Graphene increased in the last decade and it is likely to keep increasing in the near future. The attractiveness of their properties, particularly the possibility to enhance the composites performance using a tailor made methodology, brings new materials, processes and products for highly demanding industrial applications and to the market. However, there are quite a lot of...
Biocompatibility and hemocompatibility of polyvinyl alcohol hydrogel used for v...
Alexandre, Nuno; Ribeiro, Jorge; Gärtner, Andrea; Pereira, Tiago; Amorim, Irina; Fragoso, João; Lopes, Ascensão; Fernandes, João; Costa, ElísioPolyvinyl alcohol hydrogel (PVA) is a synthetic polymer with an increasing application in the biomedical field that can potentially be used for vascular grafting. However, the tissue and blood–material interactions of such gels and membranesare unknown in detail. The objectives of this study were to: (a) assess the biocompatibility and (b) hemocompatibility of PVA-based membranes in order to get some insight in...
In vitro and in vivo evaluation of blood coagulation activation of polyvinyl al...
Alexandre, Nuno; Costa, Elísio; Coimbra, Susana; Silva, Alice; Lopes, Ascensão; Rodrigues, Miguel; Santos, Marta; Maurício, Ana ColettePolyvinyl alcohol hydrogel (PVA) is a water-soluble synthetic polymer with an increasingly use in biomedical applications including vascular grafting. It was argued that the copolymerization of PVA with dextran (Dx) can result in an improvement of blood/biomaterial interactions. The focus of this experimental work is to assess that interaction through an in vivo and in vitro evaluation of the coagulation system...
The in vitro mechanical properties of small diameter Poly(vinyl) alcohol hydrog...
Alexandre, Nuno; Nunes, Natacha; Rodrigues, Miguel; Maurício, Ana Colette; Luís, Ana Lúcia; Lopes, Ascensão; Santos, José DomingosIntroduction The production of artificial vascular grafts of small diameter is a fluorescing line of investigation. PVA is a biomaterial that has been used for several biomedical applications and nowadays as a vascular graft. However the mechanical properties were never characterized in vitro. It was our objective to produce small diameter PVA grafts and characterize their physical and mechanical properties for...
In vivo evaluation of the potencial of mesenchymal stem cells (MSCs) from whart...
Alexandre, Nuno; Lopes, Ascensão; Rodrigues, Miguel; Amorim, Irina; Pereira, Tiaho; Gärtner, Andrea; Maurício, Ana Colette; Santos, José DomingosIntroduction: The use of cellular systems for improving biointegration of medical devices is a current trend of tissue engineering. The biocompatibility is a key aspect that can influence the performance of medical devices, for that reason inflammatory and foreign body reaction must be evaluated in pre-clinical studies. MSCs can modify the interaction of biomaterials with tissues by several mechanisms through t...
Application of Vascular grafts od Polyvinyl alcohol hydrogel associated to mese...
Alexandre, Nuno; Lopes, Ascensão; Nunes, Natacha; Amorim, Irina; Maurício, Ana Colette; Santos, José Domingos; Luís, Ana LúciaApplication of vascular grafts of the polyvinyl alcohol hydrogel (PVA) associated with MSCs from Wharton jelly in an animal model (sheep). N Alexandre, MA Lopes, N Fernandes, M Rodrigues, I Amorim, AC Mauricio, AL Luís Introduction: There is a great demand for new artificial vascular grafts of small diameter (< 6 mm) due to the functional limitations of the currently used biomaterials (ePTFE and Dacron). Polyvi...