3 documents found, page 1 of 1
Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pat...
Carvalho, Kevin; Faivre, Emilie; Pietrowski, Marie J.; Marques, Xavier; Gomez-Murcia, Victoria; Deleau, Aude; Huin, Vincent; Hansen, Jan NAccumulating data support the role of tau pathology in cognitive decline in ageing and Alzheimer's disease, but underlying mechanisms remain ill-defined. Interestingly, ageing and Alzheimer's disease have been associated with an abnormal upregulation of adenosine A2A receptor (A2AR), a fine tuner of synaptic plasticity. However, the link between A2AR signalling and tau pathology has remained largely unexplored....
The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfuncti...
Batalha, Vânia; Ferreira, Diana; Coelho, Joana E; Valadas, Jorge S.; Gomes, Rui; Temido Ferreira, Mariana; Shmidt, Tatiana; Baqi, Younis; Buée, LucCaffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A2A receptor (A2AR), which is upregulated in the human forebrain of aged and Alzheimer's disease (AD) patients. We have previously shown that an anti-A2AR therapy reverts age-like memory deficits, by reestablishment of the hypothalamic-pituitary-adrenal (HPA) axis feedback and corticosterone circadian lev...
From epidemiology to pathophysiology: what about caffeine in Alzheimer's disease?
Flaten, Vanessa; Laurent, Cyril; Coelho, Joana E; Sandau, Ursula; Batalha, Vânia; Burnouf, Sylvie; Hamdane, Malika; Humez, Sandrine; Boison, DetlevAD (Alzheimer's disease) is the most prevalent form of dementia in the aged population. Definitive diagnosis of AD is based on the presence of senile plaques and neurofibrillary tangles that are identified in post-mortem brain specimens. A third pathological component is inflammation. AD results from multiple genetic and environmental risk factors. Among other factors, epidemiological studies report beneficial ...