3 documents found, page 1 of 1
Effects of exercise prehabilitation on functional capacity and health-related q...
Garcia, Catarina; Leão, Inês; Pinto, Diogo; Dias Rato, Nuno; Campolargo, Ana; Dias, Isabel; Monteiro, Ana Raquel; Monteiro Soares, AdrianaHead and neck cancer (HNC) patients submitted to radical chemoradiotherapy (CRT) have to deal with various physical and psychosocial problems related to cancer and its treatment, which negatively affect functional capacity and health-related quality of life (HRQoL). Thus, the aim of this work was to analyse the impact of an exercise prehabilitation (EP) program on the functional capacity and HRQoL in HNC patien...
BEST of ASCO Portugal 2024 - ARM
Monteiro, Ana RaquelThe American Society of Clinical Oncology (ASCO) 2024 Annual Meeting highlighted several developments in supportive care, emphasizing innovative approaches to enhance care through novel interventions and personalized symptom management. This narrative review synthesizes and critically evaluates four of the main studies in supportive care presented: “REACH PC Trial: Comparative effectiveness trial of early palli...
AZD-7648, a DNA-PK Inhibitor, Induces DNA Damage, Apoptosis, and Cell Cycle Arr...
Lapa, Beatriz Santos; Costa, Maria Inês; Figueiredo, Diana; Jorge, Joana; Alves, Raquel; Monteiro, Ana Raquel; Serambeque, Beatriz; Laranjo, MafaldaThe non-homologous end joining pathway is vital for repairing DNA double-strand breaks (DSB), with DNA-dependent protein kinase (DNA-PK) playing a critical role. Altered DNA damage response (DDR) in chronic (CML) and acute myeloid leukemia (AML) offers potential therapeutic opportunities. We studied the therapeutic potential of AZD-7648 (DNA-PK inhibitor) in CML and AML cell lines. This study used two CML (K-56...