Arthropod venoms are potential sources of bioactive substances, providing tools for the validation of popular use and new drugs design. Ants belonging to the genus Dinoponera are used in the folk medicine to treat inflammatory conditions. It was previously demonstrated that the venom of the giant ant Dinoponera quadriceps (DqV), containing a mixture of polypeptides, elicit antinociceptive effect in mi...
O Ceará possui uma parcela significativa da população com alguma necessidade especial, como doenças crônico-degenerativas, infectocontagiosas e estados sindrômicos, que muitas vezes necessitam de atenção especializada e prioridade no sistema de saúde. O Núcleo de Estudos em Pacientes Especiais (NEPE) foi criado em 1997 no Curso de Odontologia da Universidade Federal do Ceará, com o objetivo de promover conhecim...
O projeto Dr. Sorriso é vinculado à Universidade Federal do Ceará, composto por 14 integrantes: 12 bolsistas do programa de educação tutorial – PET Odontologia UFC e um bolsista de extensão, sob orientação do Prof. Dr. Mário Rogério Lima Mota. O Grupo atua junto às instituições Associação Pestalozzi de Fortaleza e a Associação de Pais, Amigos e Pessoas com Deficiência de Funcionários do Banco do Brasil e da Com...
O Programa de Educação Tutorial (PET) Odontologia da Universidade Federal do Ceará iniciou suas atividades em 1988 e desde então promove e incentiva a pesquisa, o ensino e a extensão universitária. O grupo conta com doze acadêmicos integrantes e um professor tutor. Entre os acadêmicos, o grupo é composto por integrantes do 3º ao 8º período. A tutoria do grupo PET, atualmente, está a cargo do Prof. Dr. Mário Rog...
Arthropod venoms are potential sources of bioactive substances, providing tools for the validation of popular use and new drugs design. Ants belonging to the genus Dinoponera are used in the folk medicine to treat inflammatory conditions. It was previously demonstrated that the venom of the giant ant Dinoponera quadriceps (DqV), containing a mixture of polypeptides, elicit antinociceptive effect in mice models ...
Objective: To evaluate the e ff ects of dexamethasone (DEX) and nimesulide (NIM) on Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) in rats. Design: BRONJ was induced by zoledronic acid (ZA) infusion (0.2 mg/kg) in Wistar rats (n = 8), followed by extraction of the left lower fi rst molar (BRONJ groups). Control groups (n = 40) received saline (IV). For eight weeks, DEX (0.04, 0.4, 4 mg/kg) or saline (S...
Introduction: Cleft lip and palate (CLP) is the most frequent congenital malformation among the anomalies of the head and neck. The orthopedic/orthodontic treatment is included in the rehabilitation of these individuals, however there is no consensus in the literature regarding the ideal time for its beginning. Objective: To verify and characterize the profile of individuals with CLP treated at a reference hosp...
Ethnopharmacological relevance: Calycophyllum spruceanum (Benth.) Hook. F. ex K. Schum. is widely distributed in the Amazonian region of Brazil, where it is popularly known as “mulateiro”, “pau-mulato”, “pau-mulato-devárzea”, “escorrega-macaco” or “pau-marfim”. Preparations of C. spruceanum barks are used in the form of tea, poultice or skin patches to treat stomach diseases, skin inflammation and uterus tumors...
OBJECTIVES: Characterize the cell profile and immunostaining of proinflammatory markers in an experimental model of bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIALS AND METHODS: Male Wistar rats (n = 6– 7) were treated chronically with saline solution or zoledronic acid (ZA) at 0.04, 0.20, and 1.00 mg kg 1 (1.4 3 10 7, 6.9 3 10 6, and 3.4 3 10 5 mol kg 1), and subsequently, the first left inferio...
OBJECTIVES: Characterize the cell profile and immunostaining of proinflammatory markers in an experimental model of bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIALS AND METHODS: Male Wistar rats (n = 6-7) were treated chronically with saline solution or zoledronic acid (ZA) at 0.04, 0.20, and 1.00 mg kg(-1) (1.4 × 10(-7) , 6.9 × 10(-6) , and 3.4 × 10(-5) mol kg(-1) ), and subsequently, the fir...