11 documents found, page 1 of 2
Irradiação Parcial da Mama (PBI): Respiração Livre (FB) versus Apneia Inspirató...
Varzim , Patrícia; Meireles , Pedro; Casalta , João; Saraiva , Daniela; Peixoto, Patrícia; Fonseca , Filipa; Branco, Daniela; Alves , DianaEnquadramento: O ultra hipofracionamento na radioterapia adjuvante do carcinoma da mama tem demonstrado eficácia equivalente ao regime convencional [1]. A Irradiação Parcial da Mama (PBI) com 3D Conformal Radiation Therapy (3DCRT) é uma opção eficaz para tumores de baixo risco [2]. A técnica de apneia inspiratória forçada (DIBH) ajuda a reduzir a dose recebida pelos órgãos de risco (OAR) [3,4]. Objetivo: Avalia...
Multidisciplinary integration in oncology treatment: synergy in radiology & rad...
Costa, Fernando M.; Saraiva, Daniela; Fonseca, Filipa; Casalta Lopes, João; Silva , Vítor; Monteiro, Armanda; Silva , Ana Catarina; Osório, LígiaBackground: The multidisciplinary impact between magnetic resonance imaging (MRI) and radiosurgery (SRS) has revolutionized cancer treatment, enhancing precision and patient outcomes. MRI provides superior soft tissue contrast in SRS where precise and effective high doses are delivered to small target volumes [1–3]. Image-fusion between MRI and Computed Tomography (CT) provides better visualization of the targe...
Evaluation of radiotherapy doses in pediatric patients with Hodgkin Lymphoma: M...
Mota, Inês; Cravo Sá, Ana; Costa, Fernando; Monteiro, Armanda; Aires, Fátima; Faria, IsabelBackground: Hodgkin lymphoma (HL) is one of the most common cancers in children, and radiotherapy (RT) is a crucial part of treatment [1,2]. However, the risk of late effects, such as cardiotoxicity and secondary malignant neoplasms, is a concern due to radiation exposure to critical organs [2-8]. Advanced dose calculation methods, such as Monte Carlo Methods (MCMs), can improve dosimetry accuracy and help mini...
Radiotherapy metastatic prostate cancer cell lines treated with gold nanorods m...
Soares, Sílvia; Aires, Fátima; Monteiro, Armanda; Pinto, Gabriela; Faria, Isabel; Sales, Goreti; Correa-Duarte, Miguel A.; Guerreiro, SusanaMicroRNA (miRNA) modulation has been identified as a promising strategy for improving the response of human prostate cancer (PCa) to radiotherapy (RT). Studies have shown that mimics or inhibitors of miRNAs could modulate the sensitivity of PCa cells to RT. In addition, pegylated gold nanoparticles have been studied as a therapeutic approach to treat PCa cells and/or vehicles for carrying miRNAs to the inside o...
Application of Gold Nanoparticles as Radiosensitizer for Metastatic Prostate Ca...
Soares, Sílvia; Faria, Isabel; Aires, Fátima; Monteiro, Armanda; Pinto, Gabriela; Sales, M. Goreti F.; Correa-Duarte, Miguel A.; Guerreiro, Susana G.More than 50% of all prostate cancer (PCa) patients are treated by radiotherapy (RT). Radioresistance and cancer recurrence are two consequences of the therapy and are related to dose heterogeneity and non-selectivity between normal and tumoral cells. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome these therapeutic limitations of RT. This study assessed the biological interac...
Application of gold nanoparticles as radiosensitizer for metastatic prostate ca...
Soares, Sílvia; Faria, Isabel; Aires, Fátima; Monteiro, Armanda; Pinto, Gabriela; Sales, Maria Goreti; Correa-Duarte, Miguel A.; Guerreiro, Susana G.More than 50% of all prostate cancer (PCa) patients are treated by radiotherapy (RT). Radioresistance and cancer recurrence are two consequences of the therapy and are related to dose heterogeneity and non-selectivity between normal and tumoral cells. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome these therapeutic limitations of RT. This study assessed the biological interac...
Application of gold nanoparticles as radiosensitizer for metastatic prostate ca...
Soares, Sílvia; Faria, Isabel; Aires, Fátima; Monteiro, Armanda; Pinto, Gabriela; Sales, Maria Goreti; Correa-Duarte, Miguel A.; Guerreiro, Susana G.More than 50% of all prostate cancer (PCa) patients are treated by radiotherapy (RT). Radioresistance and cancer recurrence are two consequences of the therapy and are related to dose heterogeneity and non-selectivity between normal and tumoral cells. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome these therapeutic limitations of RT. This study assessed the biological interac...
Biomolecules in the relationship of cancer and obesity
Almeida, Joana; Coelho, Pedro; Prudêncio, Cristina; Vieira, Mónica; Fernandes, Rúben; Fonseca, Magda; Soares, Raquel; Silva, Liliana; Faria, IsabelObesity has been associated with various major causes of death and morbidity including malignant neoplasms. This increased prevalence has been accompanied by a worldwide increase in cutaneous melanoma incidence rates during the last decades, as well as gliomas, the most common primary malignant brain tumors in adults (Almeida et al., 2019). Although obesity aetiology is established, the implicated mechanisms re...
Oxidative Stress Modulation and Radiosensitizing Effect of Quinoxaline-1,4-Diox...
Silva, Liliana; Coelho, Pedro; Teixeira, Dulce; Monteiro, Armanda; Pinto, Gabriela; Soares, Raquel; Prudêncio, Cristina; Vieira, MónicaQuinoxaline-1,4-dioxide (QNX) derivatives are synthetic heterocyclic compounds with multiple biological and pharmacological effects. In this study, we investigated the oxidative status of quinoxaline-1,4-dioxides derivatives in modulating melanoma and glioma cell lines, based on previous results from the research group and their capability to promote cell damage by the production of Reactive Oxygen Species (ROS).
Adipocyte secretome increases radioresistance of malignant melanocytes by impro...
Coelho, Pedro; Silva, Liliana; Faria, Isabel; Vieira, Mónica; Monteiro, Armanda; Pinto, Gabriela; Prudêncio, Cristina; Fernandes, Rúben; Soares, RaquelRadiotherapy is a treatment option for the majority of malignancies. However, because melanoma is known to be radioresistant, the use of ionizing radiation as an adjuvant therapy in cutaneous melanoma patients is ineffective. Obesity has now been recognized as a risk factor for melanoma. High adiposity is generally associated with a more pro-oxidative status. Oxidative stress is a major player in radiation ther...