37 documents found, page 1 of 4
Inflammatory pain modifies reward preferences from larger delayed to smaller im...
Cerqueira-Nunes, M; Monteiro, C; Galhardo, V; Cardoso-Cruz, HSelf-control underlies goal-directed behavior in both humans and rodents. The ability to balance immediate and delayed gratification is essential for fine-tuning decision-making processes to achieve optimal rewards. Although delayed gratification has been extensively studied using human neuropsychological assessments, brain imaging techniques, and preclinical research, the impact of chronic pain on these proces...
Neuromodulation of Dopamine D2 Receptors Alters Orbitofrontal Neuronal Activity...
Dourado, M; Monteiro, C; Helder Cardoso-Cruz; Vasco Galhardo; Clara Monteiro; Margarida DouradoDopamine (DA) is believed to play a crucial role in maintaining the integrity of the rodent orbitofrontal cortex (OFC) networks during risk-based decision-making processes. Chronic pain conditions can lead to impaired DAergic signaling, which, in turn, may affect the motivational control of risk-based responses. Nevertheless, the neural mechanisms underlying this instability are poorly understood. In this study...
Dhvar5-chitosan nanogels and their potential to improve antibiotics activity
Costa, B; Alves, PM; Fonseca, DR; Campos, F; Monteiro, AC; Shahrour, H; Gomes, A; Costa, F; Gomes, P; Martínez-de-Tejada, G; Monteiro, C; Martins, MCLInfection is one of the main causes of orthopedic implants failure, with antibiotic-resistant bacteria playing a crucial role in this outcome. In this work, antimicrobial nanogels were developed to be applied in situ as implant coating to prevent orthopedic-device-related infections. To that regard, a broad-spectrum antimicrobial peptide, Dhvar5, was grafted onto chitosan via thiol-norbornene "photoclick" chemi...
Paving the way for a non‐antibiotic and microbiota friendly therapy for Helicob...
Seabra, CL; Pinho, AS; Nunes, C; Amorim, I; Pedro, N; Henriques, P; Monteiro, C; Gomes, J; Machado, C; Gartner, F; Pereira, L; Reis, S; Reis, CABackground: The World Health Organization has identified Helicobacter pylori, a Gram-negative bacterium responsible for several gastric disorders, as one of the pathogenic bacteria that requires newer non-antibiotic approaches for its management. We previously demonstrated that nanostructured lipid carriers (NLC) loaded with docosahexaenoic acid (DHA-NLC)have excellent in vitro performance against H. pylori. Ma...
Dhvar5- and MSI78-coated titanium are bactericidal against methicillin-resistan...
Costa, B; Coelho, J; Silva, V; Shahrour, H; Costa, NA; Ribeiro, AR; Santos, SG; Costa, F; Martínez-de-Tejada, G; Monteiro, C; Martins, MCLInfection is one of the major issues associated with the failure of orthopedic devices, mainly due to implant bacterial colonization, biofilm formation, and associated antibiotic resistance. Antimicrobial peptides (AMP) are a promising alternative to conventional antibiotics given their broad-spectrum of activity, low propensity to induce bacterial resistance, and ability to modulate host immune responses. Dhva...
Exploring innovative adhesive approaches to manage medical adhesive-related ski...
Fialho, L; Albuquerque, J; Pinho, AS; Pereira, AM; Monteiro, C; Oliveira, N; Ferreira, S; Martins, MCLMedical adhesives are essential to secure wound care dressings and medical devices to the skin, to bind wound edges, track vital signs, or even provide local drug delivery. Despite several options in the market, most medical adhesives are composed of acrylate, hydrocolloid, and silicone, materials that are associated with the development of Medical Adhesive-Related Skin Injury (MARSI). Moreover, these injuries ...
Effect of NaOH etching and oxygen plasma treatments on surface characteristics ...
Costa, NA; Ribeiro, AR; Rossi, AL; Monteiro, C; Lisboa, PN; Martins, MCLActivation treatments such as NaOH etching or O2 plasma can play an essential role in surface conjugation of titanium with biomolecules, providing a better interaction at the bone-implant interface. However, their application on complex titanium dioxide (TiO2) surfaces is still not explored. In this contribution, bioactive and porous TiO2 coatings produced by micro-arc oxidation (MAO) were treated with NaOH etc...
Influence of Immobilization Strategies on the Antibacterial Properties of Antim...
Barbosa, M; Alves, PM; Costa, F; Monteiro, C; Parreira, P; Teixeira, C; Gomes, P; Martins, MCLIt is key to fight bacterial adhesion to prevent biofilm establishment on biomaterials. Surface immobilization of antimicrobial peptides (AMP) is a promising strategy to avoid bacterial colonization. This work aimed to investigate whether the direct surface immobilization of Dhvar5, an AMP with head-to-tail amphipathicity, would improve the antimicrobial activity of chitosan ultrathin coatings. The peptide was ...
Antimicrobial peptide-grafted PLGA-PEG nanoparticles to fight bacterial wound i...
Ramôa, AM; Campos, F; Moreira, L; Teixeira, C; Leiro, V; Gomes, P; Neves, J; Martins, MCL; Monteiro, CWound infection treatment with antimicrobial peptides (AMPs) is still not a reality, due to the loss of activity in vivo. Unlike the conventional strategy of encapsulating AMPs on nanoparticles (NPs) leaving activity dependent on the release profile, this work explores AMP grafting to poly(D,L-lactide-co-glycolide)-polyethylene glycol NPs (PLGA-PEG NPs), whereby AMP exposition, infection targeting and immediate...
Thiol-Norbornene Photoclick Chemistry for Grafting Antimicrobial Peptides onto ...
Alves, PM; Pereira, RF; Costa, B; Tassi, N; Teixeira, C; Leiro, V; Monteiro, C; Gomes, P; Costa, F; Martins, MCLCovalent conjugation of antimicrobial peptides (AMP) is considered an effective approach to overcome their potential degradation in vivo. As the high cost of AMP-based therapies is one of the major hurdles towards their clinical application, it is urgently needed to explore high yield reactions. Herein, the highly efficient thiol-norbornene photoclick chemistry (TNPC) was explored for AMP grafting onto chitosan...