32 documents found, page 1 of 4
Chronic intermittent hypoxia-induced cardiovascular and renal dysfunction
Arnaud, Claire; Billoir, Emma; de Melo Junior, Antonio F.; SA, Pereira; O'Halloran, Ken D.; Monteiro, E.C.Funding Information: This work was supported by the Fundação para Ciência e Tecnologia [PTDC/MED‐TOX/30418/2017], iNOVA4Health [UID/Multi/04462/2013] and E.B. is recipient of a PhD fellowship from ‘Fondation pour la recherche Médicale’ (France). Publisher Copyright: © 2023 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.; Chronic intermittent hypo...
Oxalate (dys)Metabolism
Baltazar, Pedro; de Melo Junior, Antonio Ferreira; Fonseca, Nuno Moreira; Lança, Miguel Brito; Faria, Ana; Sequeira, Catarina O.; Teixeira-Santos, LuísaFunding Information: The authors would like to thank the Associação Portuguesa de Urologia, for funding the project “Precision Urology: Metabolic Phenotype of Patients with Metabolic Syndrome Traits and Recurrent Nephrolithiasis—Metabolomics and Recurrence Assessment”. iNOVA4Health research program (UIDP/04462/2020) is also acknowledged to support Judit Morello. Publisher Copyright: © 2023 by the authors.; Oxal...
Dysmetabolism and Sleep Fragmentation in Obstructive Sleep Apnea Patients Run I...
V Conde, Silvia; Martins, Fátima O.; Dias, Sara S.; Pinto, Paula; Bárbara, Cristina; Monteiro, E.C.Funding Information: This research was funded by the Portuguese Science and Technology Foundation (FCT) with the grant number CEECIND/04266/2017. Acknowledgments: The authors would like to thank Eunice Silva for technical support. Funding Information: Funding: This research was funded by the Portuguese Science and Technology Foundation (FCT) with the grant number CEECIND/04266/2017.; Daytime hypersomnolence, th...
Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and ...
Correia, Maria João; Pimpão, António B.; Fernandes, Dalila G.F.; Morello, Judit; Sequeira, Catarina O.; Calado, Joaquim; Antunes, Alexandra M.M.Funding Information: This research was supported by Fundação para a Ciência e Tecnologia (PTDC/MED-TOX/30418/2017) and iNOVA4Health (UID/Multi/04462/2013). M.J.C., D.G.F.F. and J.M. were supported by FCT (PhD grant SFRH/BD/131331/2017, PhD grant PD/BD/135484/2018 and postdoctoral contract PTDC/MED-TOX/30418/2017, respectively).; In this review encouraged by original data, we first provided in vivo evidence that...
Aryl hydrocarbon receptor and cysteine redox dynamics underlie (Mal)adaptive me...
Correia, Maria João; Pimpão, António B.; Lopes-Coelho, Filipa; Sequeira, Catarina O.; Coelho, Nuno R.; Gonçalves-Dias, Clara; Barouki, RobertFunding Information: Funding: This work was supported by Fundação para Ciência e Tecnologia [PTDC/MED-TOX/30418/2017] and iNOVA4Health [UID/Multi/04462/2013]. M.J.C., F.L.-C., N.R.C., C.G.-D. and J.M. are supported by FCT grants [SFRH/BD/131331/2017, PD/BD/128337/2017, PD/BD/114257/2016, and PD/BD/105892/2014, PTDC/MED-TOX/30418/2017 respectively]. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Base...
European survey on national harmonization in clinical research
Magnin, Annette; Iversen, Valentina Cabral; Calvo, Gonzalo; Čečetková, Beata; Dale, Ola; Demlová, Regina; Blaskó, György; Keane, FionnualaBackground: Clinical trials remain key to the development of evidence-based medical practice. However, they are becoming increasingly complex, mainly in a multinational setting. To address these challenges, the European Union (EU) adopted the Clinical Trial Regulation EU No. 536/2014 (CTR). Once in force, the CTR will lead to more consistent rules and simplification of procedures for conducting clinical trials ...
Investigator Initiated Clinical Trials (IICTs)
Madeira, C.; Hořavová, L.; dos Santos, F.; Batuca, J. R.; Nebeska, K.; Součková, L.; Kubiak, C.; Demotes, J.; Demlová, R.; Monteiro, E.C.Funding: In the Czech Republic, this work was supported by the European Regional Development Fund - Project CZECRIN_4 PACIENTY (No. CZ.02.1.01/0.0/0.0/16_013/0001826) and Large Research infrastructure CZECRIN – LM2015090. CM and FS were supported by Fundação para a Ciência e a Tecnologia (FCT, through the membership fees to ECRIN-ERIC published at Portaria nº 237/2014). The funders did not interfere with the de...
Switching from a traditional undergraduate programme in (clinical) pharmacology...
Brinkman, David J.; Monteiro, Teresa; Monteiro, E.C.; Richir, Milan C.; van Agtmael, Michiel A.; Tichelaar, JellePurpose: The pharmacology and clinical pharmacology and therapeutics (CPT) education during the undergraduate medical curriculum of NOVA Medical School, Lisbon, Portugal, was changed from a traditional programme (i.e. discipline-based, lectures) to a problem-based learning (PBL) programme (i.e. integrated, case-based discussions) without an increase in teaching hours. The aim of this study was to investigate wh...
Chronic intermittent hypoxia induces early-stage metabolic dysfunction independ...
Martins, Fátima O.; Sacramento, Joana F.; Olea, Elena; Melo, Bernardete F.; Prieto-Lloret, Jesus; Obeso, Ana; Rocher, Asuncion; Matafome, PauloFunding Information: Funding: The present study was supported by grant reference BFU2015-70616-R (MINECO/FEDER; DGICYT), and VA106G18 (JCyL), Spain and by the Portuguese Foundation for Science and Technology with contracts for Fátima O. Martins (CEECIND/04266/2017) and Joana F. Sacramento (CEEC IND/02428/2018) and a PhD Grant for Bernardete F. Melo (PD/BD/128336/2017). Publisher Copyright: © 2021 by the authors...
A simple method to measure sulfonation in man using paracetamol as probe drug
Marto, Natália; Morello, Judit; Antunes, Alexandra M.M.; Azeredo, Sofia; Monteiro, E.C.; SA, PereiraSulfotransferase enzymes (SULT) catalyse sulfoconjugation of drugs, as well as endogenous mediators, gut microbiota metabolites and environmental xenobiotics. To address the limited evidence on sulfonation activity from clinical research, we developed a clinical metabolic phenotyping method using paracetamol as a probe substrate. Our aim was to estimate sulfonation capability of phenolic compounds and study its...