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Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene si...

Silva, Manuela; Viegas, Wanda; Earley, Keith; Lawrence, Richard; Pontes, Olga; Reuther, Rachel; Enciso, Angel; Neves, Nuno; Gross, Michael

Nucleolar dominance describes the silencing of one parental set of ribosomal RNA (rRNA) genes in a genetic hybrid, an epigenetic phenomenon that occurs on a scale second only to X-chromosome inactivation in mammals. An RNA interference (RNAi) knockdown screen revealed that the predicted Arabidopsis histone deacetylase, HDA6, is required for rRNA gene silencing in nucleolar dominance. In vivo, derepression of si...

Date: 2006   |   Origin: Repositório da Universidade de Lisboa
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