38 documents found, page 1 of 4
Tradução, Adaptação Transcultural e Validade de Instrumentos de Coleta de Dados...
Oliveira, Paulo; Pereira, Beatriz; Monteiro, EstelaO cyberbullying é um fenômeno que está em crescimento, principalmente após a Pandemia de COVID – 19 e que pode provocar problemas de saúde mental em crianças e adolescentes. O objetivo deste estudo foi realizar a tradução, a adaptação transcultural e a validade de conteúdo do Cyber-aggression Questionnaire for Adolescents – CYBA (Álvarez-García et al., 2016) e do Cybervictimization Questionnaire for Adolescents...
Avaliação das aprendizagens de inglês no 1º CEB: um estudo em Portugal continental
Moreira, Maria Alfredo; Mourão, Sandie; Leslie, Carolyn; Monteiro, EstelaEste relatório descreve os resultados de um estudo exploratório, de âmbito nacional, que investigou as práticas de avaliação no Ensino Primário de Inglês em Portugal. O estudo, organizado através do CETAPS, Universidade Nova de Lisboa, em colaboração com o CIEd da Universidade do Minho, decorreu entre outubro de 2017 e dezembro de 2019 com os seguintes objetivos: Analisar as perceções, abordagens e práticas uti...
School experience, failure, and dropout: the students’ perspectives
Moreira, Maria Alfredo; Patacho, Pedro; Monteiro, Estela; Vázquez Recio, Rosa; López Gil, MónicaThis paper embraces two complementary studies of the same international project, a qualitative study on the influence of educational, family, and sociocultural contexts on at-risk students and school dropout. In this paper, abandonment/dropping-out is clearly not a terminal phenomenon but a complex process that for most of the students started in primary education and continued with their entry in compulsory se...
Alpha-thalassemia due to novel deletions and complex rearrangements in the subt...
Ferrão, José; Silva, Marisa; Gonçalves, Lúcia; Gomes, Susana; Loureiro, Pedro; Coelho, Andreia; Miranda, Armandina; Seuanes, Filomena; Batalha Reis, AnaIntroduction: Inherited deletions removing the α-globin genes and/or their upstream regulatory elements (MCSs) give rise to alpha-thalassemia, one of the most common genetic recessive disorders worldwide. The pathology is characterized by microcytic hypochromic anemia due to reduction of the α-globin chain synthesis, which are essential for hemoglobin tetramerization. Material and Methods: In order to clarify t...
Widening the spectrum of deletions and molecular mechanisms underlying alpha-th...
Ferrão, José; Silva, Marisa; Gonçalves, Lúcia; Gomes, Susana; Loureiro, Pedro; Coelho, Andreia; Miranda, Armandina; Seuanes, Filomena; Reis, Ana BatalhaInherited deletions of α-globin genes and/or their upstream regulatory elements (MCSs) give rise to α-thalassemia, an autosomal recessive microcytic hypochromic anemia. In this study, Multiplex Ligation-dependent Probe Amplification performed with commercial and synthetic engineered probes, Gap-PCR, and DNA sequencing were used to characterize lesions in the subtelomeric region of the short arm of chromosome 16...
Alpha-thalassemia due to novel deletions and complex rearrangements in the subt...
Ferrão, José; Silva, Marisa; Gonçalves, Lúcia; Gomes, Susana; Loureiro, Pedro; Coelho, Andreia; Miranda, Armandina; Seuanes, Filomena; Batalha Reis, AnaIntroduction: Inherited deletions removing the α-globin genes and/or their upstream regulatory elements (MCSs) give rise to alpha-thalassemia, one of the most common genetic recessive disorders worldwide. The pathology is characterized by microcytic hypochromic anemia due to reduction of the α-globin chain synthesis, which are essential for hemoglobin tetramerization. Material and Methods: In order to clarify t...
Unusual molecular mechanisms in the origin of alpha-thalassemia
Ferrão, José; Silva, Marisa; Gonçalves, Lúcia; Gomes, Susana; Loureiro, Pedro; Coelho, Andreia; Miranda, Armandina; Seuanes, Filomena; Batalha Reis, AnaHemoglobin (Hb) is a protein responsible for oxygen transportation from lungs to the entire body. It is composed by four globular subunits - the globins - each with a central core containing a heme molecule. Globins are encoded by the α- and β-globin gene clusters located at 16p13.3 and 11p15.5, respectively. The pattern of globin gene expression during development is precisely controlled by the interaction of ...
Widening the spectrum of deletions and molecular mechanisms underlying alpha-th...
Ferrão, José; Silva, Marisa; Gonçalves, Lúcia; Gomes, Susana; Loureiro, Pedro; Coelho, Andreia; Miranda, Armandina; Seuanes, Filomena; Reis, Ana BatalhaInherited deletions of α-globin genes and/or their upstream regulatory elements (MCSs) give rise to α-thalassemia, an autosomal recessive microcytic hypochromic anemia. In this study, multiplex ligation-dependent probe amplification performed with commercial and synthetic engineered probes, Gap-PCR, and DNA sequencing were used to characterize lesions in the sub-telomeric region of the short arm of chromosome 1...
Familial amyloid polyneuropathy (FAP): clinical features, pathophysiology and t...
Tomás, Maria Teresa; Santa-Clara, Helena; Mateus, Élia; Monteiro, EstelaIn the literature, concepts of “polyneuropathy”, “peripheral neuropathy” and “neuropathy” are often mistakenly used as synonyms. Polyneuropathy is a specific term that refers to a relatively homogenous process that affects multiple peripheral nerves. Most of these tend to present as symmetric polyneuropathies that first manifest in the distal portions of the affected nerves. Many of these distal symmetric polyn...
The impact of exercise training on liver transplanted familial amyloidotic poly...
Tomás, Maria Teresa; Santa-Clara, Helena; Bruno, Paula Marta; Monteiro, Estela; Carrolo, Margarida; Barroso, Eduardo; Sardinha, Luís B.; Fernhall, BoLiver transplantation is nowadays the only effective answer to adjourn the outcome of functional limitations associated with familial amyloidotic polyneuropathy (FAP), a neurodegenerative disease characterized by sensory and motor polyneuropathies. Nevertheless, there is a detrimental impact associated with the after-surgery period on the fragile physical condition of these patients. Exercise training has been ...