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Alginate-nanohydroxyapatite hydrogel system: Optimizing the formulation for enh...

Barros, J.; Ferraz, Maria Pia; Azeredo, J.; Fernandes, M.H.; Gomes, P.S.; Monteiro, F.J.

Ceramic/polymer-based biocomposites have emerged as potential biomaterials tofill, replace, repair or re-generate injured or diseased bone, due to their outstanding features in terms of biocompatibility, bioactivity,injectability, and biodegradability. However, these properties can be dependent on the amount of ceramiccomponent present in the polymer-based composite. Therefore, in the present study, the influen...


Anti-sessile bacterial and cytocompatibility properties of CHX-loaded nanohydro...

Barros, J.; Grenho, Liliana; Fernandes, M.H.; Manuel, C.M.; Melo, L.F.; Nunes, O.C.; Monteiro, F.J.; Ferraz, Maria Pia

Nanohydroxyapatite possesses exceptional biocompatibility and bioactivity regarding bone cells and tissues, justifying its use as a coating material or as a bone substitute. Unfortunately, this feature may also encourage bacterial adhesion and biofilm formation. Surface functionalization with antimicrobials is a promising strategy to reduce the likelihood of bacterial infestation and colonization on medical dev...


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