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Ultrasound stimulation increases cartilage synthesis and revert dedifferentiati...
Oliveira, Sofia; Ferreira, Débora Carina Gonçalves Abreu; Padrão, Jorge; Catarino, Susana Oliveira; Monteiro, Francisca Andreia Azevedo; Zille, AndreaTherapeutic ultrasound (US) holds promise as a potential therapy to treat articular cartilage; however, optimized and targeted US protocols are lacking. This study aimed at determining an appropriate set of US protocols for stimulating human chondrocyte activity. Human chondrocytes were exposed to various US parameters, including different central frequencies, power densities, operation modes, pulse parameters,...
Development and validation of a multi-modal customized device to stimulate in v...
Oliveira, Sofia; Monteiro, Francisca Andreia Azevedo; Catarino, Susana Oliveira; Hinckel, Betina B.; Sotiropoulos, I.; Leal, Ana Isabel Neto CardosoThis work focuses on the development and validation of a multi-modal stimulation device for in vitro cell culture systems. The device was designed to stimulate cells or tissues placed on 12-well culture plates. It is connected to customized software that controls the parameters of photobiomodulation (PBM) and ultrasound stimulation (US) through light-emitting diodes and piezoelectric disks, respectively. A wide...
Near-infrared photobiomodulation stimulates viability and cartilage matrix synt...
Oliveira, Sofia; Ferreira, Débora Carina Gonçalves Abreu; Padrão, Jorge; Catarino, Susana Oliveira; Monteiro, Francisca Andreia Azevedo; Zille, AndreaPhotobiomodulation (PBM) within red to near-infrared spectrum has been proposed as a method to restore articular cartilage injuries, due to its ability to modulate effectively chondrocyte activity, namely viability, proliferation and extracellular matrix synthesis. This in vitro study aimed to determine the most appropriate PBM dosage on human chondrocytes. Firstly, human chondrocytes were stimulated daily or e...