7 documents found, page 1 of 1

Estudo da enxaqueca em idade pediátrica nos cuidados de saúde primários da regi...

Introdução: A enxaqueca é uma cefaleia primária comum, que pode ter início em idade pediátrica. Não existem dados concretos nos cuidados de saúde primários (CSP) em Portugal. Foi objetivo deste estudo caracterizar uma população pediátrica com diagnóstico de enxaqueca em seguimento nos CSP da região Centro de Portugal, abordando aspetos demográficos, epidemiológicos e clínicos. Métodos: No primeiro trimestre de ...

Hydrogen peroxide as a key player in bystander effects

Glycans as Key Checkpoints of T Cell Activity and Function

The immune system is highly controlled and fine-tuned by glycosylation, through the addition of a diversity of carbohydrates structures (glycans) to virtually all immune cell receptors. Despite a relative backlog in understanding the importance of glycans in the immune system, due to its inherent complexity, remarkable findings have been highlighting the essential contributions of glycosylation in the regulatio...

Metabolic control of T cell immune response through glycans in inflammatory bow...

Mucosal T lymphocytes from patients with ulcerative colitis (UC) were previously shown to display a deficiency in branched N-glycosylation associated with disease severity. However, whether this glycosylation pathway shapes the course of the T cell response constituting a targeted-specific mechanism in UC remains largely unknown. In this study, we demonstrated that metabolic supplementation of ex vivo mucosal T...

Absence of IFN gamma promotes hippocampal plasticity and enhances cognitive per...

Cognitive functioning can be differentially modulated by components of the immune system. Interferon-γ (IFNγ) is a pro-inflammatory cytokine whose production is altered in many conditions displaying some degree of cognitive deficits, although its role in cognitive functioning is still unclear. Here we show that the absence of IFNγ selectively enhances cognitive behaviours in tasks in which the hippocampus is impl...

The impact of chronic stress on the rat brain lipidome

Chronic stress is a major risk factor for several human disorders that affect modern societies. The brain is a key target of chronic stress. In fact, there is growing evidence indicating that exposure to stress affects learning and memory, decision making and emotional responses, and may even predispose for pathological processes, such as Alzheimer's disease and depression. Lipids are a major constituent of the...

Development of computer-based virtual patients for training and assessment of s...